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CREB1 — EGF
Text-mined interactions from Literome
Zhang et al., Neurobiol Aging 1999
(Alzheimer Disease...) :
Oxidative stress differentially modulates phosphorylation of ERK, p38 and
CREB induced by NGF or
EGF in PC12 cells
Arthur et al., FEBS Lett 2000
:
TPA and
EGF induced the phosphorylation of cyclic AMP-responsive element binding protein (
CREB ) at Ser-133 and ATF1 at Ser-63 in wild type cells and this was abolished by inhibition of the mitogen activated protein kinase cascade
Merienne et al., Mol Cell Biol 2001
:
The protein kinase ribosomal S6 kinase 2 (RSK2) has been implicated in phosphorylation of transcription factor
CREB and histone H3 in
response to mitogenic stimulation by
epidermal growth factor
Grimes et al., J Neurochem 2001
:
Conversely, overexpression of active GSK3 beta to 3.5-fold the normal levels completely blocked increases in
CREB DNA binding activity
induced by
epidermal growth factor , insulin-like growth factor-1, forskolin, and cyclic AMP
Swarthout et al., J Bone Miner Res 2002
:
Here, we show, using the GAL4-CREB reporter system, that
epidermal growth factor (EGF) can
transactivate CREB in UMR cells in addition to PTH ...
EGF activates members of the MAPK family including p38 and extracellular signal activated kinases ( ERKs ), and treatment of UMR cells with either the p38 inhibitor ( SB203580 ) or the MEK inhibitor ( PD98059 )
prevents phosphorylation of
CREB at S133 by EGF but not by PTH ... Treatment of cells with either SB203580 or PD98059 alone or together significantly inhibits transactivation of CREB by EGF but not by PTH, indicating that
EGF regulates
CREB phosphorylation and transactivation through p38 and ERKs and PTH does not
Wang et al., Mol Biol Cell 2005
(Inflammation) :
Moreover, the phosphatidylinositol 3 (PI3)-kinase inhibitor ( wortmannin ) and p38 ( MAPK ) inhibitor ( SB203580 ) inhibited the
EGF induced
CREB phosphorylation and the expression of NF-IL6beta gene in cells
Neithardt et al., J Cell Physiol 2006
:
Both GnRH and
epidermal growth factor (EGF) caused rapid phosphorylation of cyclic AMP response element binding protein (
CREB ) and BAD
Shah et al., J Steroid Biochem Mol Biol 2006
:
Whereas, selective inhibition of EGF-R kinase with AG1478 caused complete inhibition of
EGF induced
ERK/RSK-1/CREB activation, it caused only partial reduction ( 30-40 % ) of such ET-1 induced responses ...
Activation of
ERK/RSK-1/CREB by both ET-1 and
EGF was abolished by inhibition of Src, indicating its central role in ET-1 signaling in BAG cells
Pham et al., J Cell Physiol 2008
:
Ang II and
EGF induced transient phosphorylation of ERK, p38 ( MAPK ) and
CREB ...
EGF dependent COX-2 expression and
CREB phosphorylation were inhibited by SB202190, PD98059, and AG1478
Poon et al., Mol Endocrinol 2009
(Neoplasm Invasiveness...) :
EGF increases the phosphorylation of
cAMP-responsive element binding protein ( p-CREB ) and its association with the coregulator, CCAAT/enhancer binding protein beta, whereas blocking the EGF induced ERK1/2 phosphorylation with MAPK inhibitors ( PD98059/U0126 ) markedly reduced these effects ... Chromatin immunoprecipitation assays demonstrated that
EGF induces
p-CREB binding to a cAMP responsive-element within the GnRH-II promoter, likely in association with CCAAT/enhancer binding protein beta, and mutagenesis of this cAMP responsive-element prevented EGF induced GnRH-II promoter activity in OVCAR-3 cells
Walker et al., Philos Trans R Soc Lond B Biol Sci 2010
:
Also, testosterone activation of Src,
EGF receptor and ERK kinases as well as the
activation of the
CREB transcription factor and CREB mediated transcription is reviewed
Matsumoto et al., J Biol Chem 1998
:
Although EGF did not alter the amount of CRE binding protein ( CREB ),
EGF induced
CREB phosphorylation ... Protein kinase C inhibitors ( H7, staurosporin, and chelerythrine ) inhibited
EGF induced
CREB phosphorylation, whereas either mitogen activated protein kinase kinase-1 inhibitor ( PD98059 ) or protein kinase A inhibitor ( H8 ) showed no effect
Tabernero et al., Mol Cell Neurosci 1998
:
In contrast, neurotrophins, CNTF, FGF-2,
EGF , and TGF beta
induce little or no phosphorylation of
CREB despite the fact that receptors for these factors are present on Schwann cells
De Cesare et al., Proc Natl Acad Sci U S A 1998
:
Rsk-2 activity is necessary for
epidermal growth factor induced phosphorylation of
CREB protein and transcription of c-fos gene ... Here we document that in CLS fibroblasts there is a drastic attenuation in the induced Ser-133 phosphorylation of transcription factor
CREB ( cAMP response element binding protein ) in
response to
epidermal growth factor stimulation