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ARF6 — EGF

Pathways - manually collected, often from reviews:

• NCI Pathway Database Arf6 signaling events: EGFR/EGFR/EGF/EGF/ARFGEP100 complex (EGFR-EGF-IQSEC1) → ARF6/GDP complex (ARF6) (modification, activates) Morishige et al., Nat Cell Biol 2008*
  Evidence: mutant phenotype

Text-mined interactions from Literome

Li et al., Cancer 2009 (Glioblastoma) : However, the role of ARF6 in EGF signaling is unknown ... To determine whether EGF induces ARF6 expression in human glioblastoma U87 cells through transcriptional regulation and EGFR activation, the levels of ARF6 were assayed in EGF treated U87 cells that were preincubated with a transcriptional inhibitor ( actinomycin D ) and an EGFR tyrosine kinase inhibitor ( PD153035 ), respectively ... Furthermore, EGF stimulated ARF6 expression in U87 cells in a dose dependent and time-dependant manner ... It is noteworthy that SP1 was essential for EGF induced ARF6 up-regulation ... : The results of the current study suggested that EGF induced ARF6 expression plays a significant role in glioma cell proliferation
Hu et al., Exp Cell Res 2013 (Breast Neoplasms...) : EGF increased Arf6 activity, ERK phosphorylation, and uPAR expression in a time dependent manner
Taira et al., Nephron 1994 (Acute Kidney Injury) : In summary, urinary immunoreactive EGF levels decreased and renal EGF levels increased in rats with HgCl2 induced ARF