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EFNB2 — NOTCH4
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Shawber et al., Ann N Y Acad Sci 2003
:
Notch4 activation also
induced the expression of the transcriptional repressors, HES1, HERP1, and HERP2, as well as
ephrinB2 , an angiogenic factor proposed to be involved in arterial/venous endothelial cell specification
Hainaud et al., Cancer Res 2006
(Carcinoma...) :
We also showed that the activation of
Notch4 is
required for VEGF induced up-regulation of
ephrin B2 and the differentiation of human venous endothelial cells in vitro
Limbourg et al., Circ Res 2007
(Ischemia) :
In heterozygous Dll1 mutant mice endothelial
Notch activation and
ephrin-B2 induction after hindlimb ischemia were absent, arterial collateral growth was abrogated and recovery of blood flow was severely impaired, but perivascular vascular endothelial growth factor and EphB4 expression was unaltered ... Thus, Dll1 mediated
Notch activation
regulates ephrin-B2 expression and postnatal arteriogenesis
Grego-Bessa et al., Dev Cell 2007
:
Functional and molecular analyses show that
Notch inhibition
prevents EphrinB2 expression, and that EphrinB2 is a direct Notch target acting upstream of NRG1 in the ventricles
Hunkapiller et al., Development 2011
(Pre-Eclampsia) :
Inhibition of
Notch signaling
reduced invasion of cultured human TBs and expression of the arterial marker
EFNB2