Gene interactions and pathways from curated databases and text-mining

◀ Back to NOTCH4

EFNB2 — NOTCH4

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Shawber et al., Ann N Y Acad Sci 2003 : Notch4 activation also induced the expression of the transcriptional repressors, HES1, HERP1, and HERP2, as well as ephrinB2 , an angiogenic factor proposed to be involved in arterial/venous endothelial cell specification
Hainaud et al., Cancer Res 2006 (Carcinoma...) : We also showed that the activation of Notch4 is required for VEGF induced up-regulation of ephrin B2 and the differentiation of human venous endothelial cells in vitro
Limbourg et al., Circ Res 2007 (Ischemia) : In heterozygous Dll1 mutant mice endothelial Notch activation and ephrin-B2 induction after hindlimb ischemia were absent, arterial collateral growth was abrogated and recovery of blood flow was severely impaired, but perivascular vascular endothelial growth factor and EphB4 expression was unaltered ... Thus, Dll1 mediated Notch activation regulates ephrin-B2 expression and postnatal arteriogenesis
Grego-Bessa et al., Dev Cell 2007 : Functional and molecular analyses show that Notch inhibition prevents EphrinB2 expression, and that EphrinB2 is a direct Notch target acting upstream of NRG1 in the ventricles
Hunkapiller et al., Development 2011 (Pre-Eclampsia) : Inhibition of Notch signaling reduced invasion of cultured human TBs and expression of the arterial marker EFNB2