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ECM1 — IGF1
Text-mined interactions from Literome
Oosterlaken-Dijksterhuis et al., Breast Cancer Res Treat 1999
(Mammary Neoplasms, Animal) :
The difference between IGF-I and RA was an enhanced IGFBP-5 binding to the extracellular matrix ( ECM ) by RA, whereas
IGF-I reduced binding to the
ECM
Lawrance et al., Inflamm Bowel Dis 2001
(Inflammation...) :
Our aim was to determine whether TGF-beta1 and
IGF-1 are
involved in intestinal
ECM collagen regulation and what impact the inflammatory infiltrate has on their expression
Gooch et al., J Biol Chem 2001
(Hypertrophy) :
IGF-I induced hypertrophy as determined by an increase in cell size and an increase in protein to DNA ratio and
increased accumulation of
extracellular matrix ( ECM ) proteins ... Inhibition of either MAPK or PI3K, however, had no effect on
IGF-I induced hypertrophy or
ECM production ... Therefore,
IGF-I induces hypertrophy and increases
ECM accumulation in MCs ... Therefore,
IGF-I induces hypertrophy and increases
ECM accumulation in MCs
Daian et al., J Invest Dermatol 2003
(Keloid) :
Insulin-like growth factor-I enhances transforming growth factor-beta induced
extracellular matrix protein production through the P38/activating transcription factor-2 signaling pathway in keloid fibroblasts
Singh et al., International journal of biological sciences 2007
:
Recently we demonstrated that
IGF-1 expression is increased in the diabetic kidney and that it may
involve in renal hypertrophy and
extracellular matrix protein ( ECM ) accumulation in mesangial cells as seen in diabetic glomerulopathy
Etheredge et al., Invest Ophthalmol Vis Sci 2009
:
The
effects of
IGF-I , TGF-beta1, FGF-2, and PDGF on proliferation and
ECM production by primary cultured bovine keratocytes were evaluated
Liu et al., Chin Med J (Engl) 2010
(Liver Cirrhosis) :
Insulin-like growth factor binding protein related protein 1 ( IGFBPrP1 ) can activate hepatic stellate cells and
increase extracellular matrix ( ECM ) in vitro
Devi et al., Biochim Biophys Acta 2011
(Diabetic Retinopathy) :
GSK-3ß/CREB axis mediates
IGF-1 induced
ECM/adhesion molecule expression, cell cycle progression and monolayer permeability in retinal capillary endothelial cells : Implications for diabetic retinopathy ... We therefore examined the
effect of insulin-like growth factor
(IGF)-1 on
ECM/adhesion molecule expression, cell cycle regulation and monolayer permeability in an endothelial cell line ( TR-iBRB2 )
Corrêa-Giannella et al., Diabetology & metabolic syndrome 2012
:
The objective of the present study was to investigate the
effect of an AGE modified
extracellular matrix protein on
IGF-I induced SMC proliferation and on the IGF-I-IGF binding protein 4 (IGFBP-4) axis under basal conditions and after stimulation with PDGF-BB
Pricci et al., Endocrinology 1996
:
These experiments in cultured human mesangial cells were aimed at assessing the
effects of
IGF-I and IGF-II, compared with those of TGFbeta, on 1 )
ECM medium accumulation and gene expression, and 2 ) total protein synthesis and cell proliferation