Gene interactions and pathways from curated databases and text-mining

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AKT1 — E2F8

Text-mined interactions from Literome

Gille et al., J Biol Chem 1999 : Activated PI 3-kinase induces cyclin D(1) transcription and E2F activity, at least in part mediated by the serine/threonine kinase Akt/PKB , and to a lesser extent the Rho family GTPase Rac ... Activated PI 3-kinase induces cyclin D(1) transcription and E2F activity, at least in part mediated by the serine/threonine kinase Akt/PKB , and to a lesser extent the Rho family GTPase Rac
Chaussepied et al., Mol Cell 2004 : Transcriptional regulation of AKT activation by E2F ... We identify the adaptor protein Grb2 associated binder 2 (Gab2) as a direct E2F target gene and an essential effector of E2F dependent AKT activation
Yin et al., Prostate 2009 (Prostatic Neoplasms) : In prostate cancer C/EBPalpha promotes cell growth by the loss of interactions with CDK2, CDK4, and E2F and by activation of AKT
Dar et al., J Biol Chem 2011 (Melanoma...) : The proliferative capacity of melanoma cells was suppressed by miR-205 and mediated by E2F regulated AKT phosphorylation
Brennan et al., Immunity 1997 : The expression of an active PKB is sufficient to induce E2F activity