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E2F1 — IGF2

Text-mined interactions from Literome

Zheng et al., Cancer Res 2009 (Prostatic Neoplasms) : E2F1 up-regulated the production of EGR1 induced growth factors, epidermal growth factor, platelet derived growth factor, and insulin-like growth factor II , which in turn activated the phosphoinositide-3-kinase/Akt pathway to resist drug induced apoptosis
Schayek et al., Growth Horm IGF Res 2010 (Prostatic Neoplasms) : The aim of this study was to investigate the involvement of E2F1 in regulation of IGF-IR gene transcription ... Furthermore, deletion and bioinformatic analyses indicate that the ability of E2F1 to stimulate IGF-IR promoter activity was correlated with the number of E2F1 sites in the promoter region ... In summary, we provide evidence that E2F1 regulates IGF-IR gene transcription in prostate cancer cells via a mechanism that involves direct binding to specific elements in the proximal IGF-IR promoter