Gene interactions and pathways from curated databases and text-mining

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DUSP7 — MAPK3

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: MAPK3 → DUSP7 (directlyDecreases, DUSP7 Activity, MAPK3 Activity)
    Evidence: The second subfamily comprises DUSP6, DUSP7 and DUSP9. They consist of 3 exons, are cytoplasmic in their subcellular localization and preferentially recognize ERK1 and ERK2 in vitro.
  • KEGG MAPK signaling pathway: DUSP1/DUSP10/DUSP14/DUSP16/DUSP2/DUSP22/DUSP3/DUSP4/DUSP5/DUSP6/DUSP7/DUSP8/DUSP9 → MAPK1/MAPK3 (protein-protein, inhibition)
  • Reactome Reaction: DUSP7 → MAPK3 (reaction) Amit et al., Nat Genet 2007

Text-mined interactions from Literome

Givant-Horwitz et al., Gynecol Oncol 2004 (MAP Kinase Signaling System...) : The objective of the present study was to investigate the expression and clinical role of dual-specificity phosphatases ( DUSP ) , inhibitors of MAPK signaling, in ovarian cancer cells at this site
Kumabe et al., Microbiol Immunol 2010 : Activation of MAPK is negatively regulated by DUSP , which dephosphorylate the phosphothreonine and phosphotyrosine residues