Gene interactions and pathways from curated databases and text-mining

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DUSP1 — TLR4

Text-mined interactions from Literome

Cho et al., Arch Biochem Biophys 2008 : TLR4L treatment induced MKP-1 through gene transcription
Wang et al., Mucosal Immunol 2010 : To gain insight into tolerance at the level of the proinflammatory mitogen activated protein kinase ( MAPK ) p38, we characterized TLR mediated induction of the p38-specific phosphatase MKP-1
Tsai et al., PloS one 2011 : These results strongly suggest that Der-p2 is capable of triggering B cell activation and MKP-1 activated p38/MAPK dephosphorylation regulated TLR4 induction, which subsequently enhances host immune, defense responses and development of effective allergic disease therapeutics in B cells