Gorostizaga et al., Mol Cell Endocrinol 2007
:
In adrenocortical and Leydig cells PKA activation by trophic hormones increases the activity of protein tyrosine phosphatases and also induces the expression of MAP kinase phosphatase 1 (MKP-1) , a dual activity protein phosphatase ( serine/threonine and tyrosine )
Cho et al., Inflamm Res 2009
:
In view of the potential roles of PKA and MSK for MKP-1 induction and the ability of H89 to inhibit these kinases, this study examined the effect of H89 on MKP-1 induction by LPS and the role of cyclic-AMP response element binding protein ( CREB ) in the MKP-1 induction
Lee et al., J Biol Chem 2012
(MAP Kinase Signaling System...) :
PDE4B inhibits MKP-1 expression in a cAMP-PKA dependent manner