Gene interactions and pathways from curated databases and text-mining

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DUSP1 — MAPK14

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Viñals et al., Mol Cell Biol 1999 : Enforced long-term activation of p42/p44 MAPK by expression of the chimera DeltaRaf-1 : ER, which activates the p42/p44 MAPK cascade at the level of Raf, enhanced the expression of MKP1/2 and cyclin D1 and, more importantly, restored the reentry of confluent cells into the cell cycle
Brondello et al., Science 1999 (MAP Kinase Signaling System) : MKP-1 was a target in vivo and in vitro for p42(MAPK) or p44(MAPK), which phosphorylates MKP-1 on two carboxyl-terminal serine residues, Serine 359 and Serine 364
Kim et al., Biochem Biophys Res Commun 2000 : Regulation of MKP-1 by MAPK likely represents an important negative-feedback mechanism
Reffas et al., Biochem J 2000 : Activation of mitogen activated protein kinases ( MAPKs ), their upstream activators MAPK kinases ( MAPKKs or MEKs ) and induction of MKP-1 ( CL100/3CH134 ) and MKP-3 ( Pyst1/rVH6 ) dual-specificity MAPK phosphatases ( MKPs ) were studied in the mouse embryonic stem cell line P19 during the 7 day induction of neuronal differentiation triggered by aggregation and retinoic acid
Byon et al., Mol Cell Biochem 2001 : However, inhibition of p38MAPK activity by SB202190 had no effect on insulin stimulated MKP-1 induction ... In conclusion, induction of MKP-1 mRNA expression in Hirc B cells by insulin requires activation of both the ERK and JNK pathways, but not p38MAPK
Liao et al., Gastroenterology 2003 (Chronic Disease...) : In view of the important role of MAPK kinase phosphatase (MKP)-1 in the regulation of MAPK activation, the expression and functional role of MKP-1 was analyzed ... MKP-1 down-regulation led to decreased proliferation and sustained MAPK activation in response to mitogens
Zhao et al., Biochem Pharmacol 2003 : Increased MKP-1 expression was dependent on the mitogen activated protein kinase , Erk
Givant-Horwitz et al., Gynecol Oncol 2004 (MAP Kinase Signaling System...) : The objective of the present study was to investigate the expression and clinical role of dual-specificity phosphatases ( DUSP ) , inhibitors of MAPK signaling, in ovarian cancer cells at this site
Vicent et al., Clin Cancer Res 2004 (Carcinoma, Non-Small-Cell Lung...) : Immunohistochemistry in NSCLC resection specimens showed high levels of CL100/MKP-1 and activation of the three MAPK compared with normal lung
Sakaue et al., J Biol Chem 2004 (MAP Kinase Signaling System) : Although the phosphorylation or abundance of MEK, an upstream kinase for p42/p44 MAPK, was not altered during differentiation, the abundance of MAPK phosphatase-1 (MKP-1) , a negative regulator of p42/p44 MAPK , was increased with a time course similar to that of the down-regulation of p42/p44 MAPK activity ... Ectopic expression of MKP-1 in preadipocytes reduced and depletion of endogenous MKP-1 in mature adipocytes increased the activity of p42/p44 MAPK
Jacob et al., Am J Physiol Cell Physiol 2004 (Diabetes Mellitus, Type 2...) : Adenoviral expression of cGK Ialpha enhanced MKP-1 inhibition of MAPK phosphorylation and VSMC migration
Toh et al., Arthritis Rheum 2004 (Arthritis, Rheumatoid) : Moreover, inhibition of MKP-1 expression impaired dexamethasone mediated inhibition of MAPK phosphorylation
Gorostizaga et al., Biochem Biophys Res Commun 2005 : Heat shock triggers MAPK activation and MKP-1 induction in Leydig testicular cells
Chansard et al., Brain Res Mol Brain Res 2005 : Taken together, our data suggest that cAMP induced Aa-Nat and Period1 are likely to be mediated by activation of JNK, whereas MKP-1 may be mediated by both p38 ( MAPK ) and JNK activations
Chi et al., Proc Natl Acad Sci U S A 2006 (Shock, Septic) : MKP-1 deficiency led to sustained activation of p38 MAPK and c-Jun N-terminal kinase (JNK) in LPS treated macrophages
Mikami et al., J Biol Chem 2006 (Bacterial Infections) : Another involves MAP kinase phosphatase 1 (MKP-1) dependent inhibition of p38 MAPK , a known negative regulator for TLR2 induction
Yang et al., J Immunol 2006 : MAPK phosphatase-1 (MKP-1) , a glucocorticoid induced negative regulator of MAPK activation, was up-regulated by dexamethasone in WT cells, but this effect of dexamethasone was significantly impaired in Anx-1 ( -/- ) cells ... Treatment of Anx-1 ( -/- ) cells with Anx-1 N-terminal peptide restored MKP-1 expression and inhibited p38 MAPK activity
Morisco et al., Cardiovasc Res 2007 (Insulin Resistance) : Insulin induced MKP-1 expression was mediated by extracellular signal regulated protein kinases ( ERK ) 1/2, c-Jun NH2-terminal kinases (JNK) MAPK , and phosphatidylinositol 3-kinase (PI3K)/Akt pathways
Horsch et al., Mol Endocrinol 2007 : Neither c-jun N-terminal kinase nor p38 MAPK is activated by the mitogenic cocktail in 20 % fetal calf serum, but their activation by a DNA damaging agent ( UV irradiation ) was inhibited by either GC treatment or overexpression of MKP-1 , indicating regulation of all three MAPKs by MKP-1 in osteoblasts
Kim et al., Neurosci Lett 2008 (Glioma) : Moreover, pharmacological inhibition of p38 MAPK by SB203580 suppressed the cadmium induced MKP-1
Chi et al., Science signaling 2008 (Inflammation...) : A study now demonstrates that MKP-1 is also acetylated on a key lysine residue following stimulation of TLRs. Acetylation of MKP-1 promotes the interaction of MKP-1 with its substrate p38 MAPK , which results in dephosphorylation of p38 MAPK and the inhibition of innate immunity
Pae et al., Neurosci Lett 2009 : Curcumin attenuated ethanol induced cell death, inhibited activation of p38 MAPK , and activated MKP-1
King et al., J Biol Chem 2009 : Adenoviral expression of MKP-1 profoundly reduces p38 MAPK phosphorylation and IL-8 expression ... Thus, MKP-1 attenuates TNFalpha dependent activation of p38 MAPK , induction of IL-8 expression, and NF-kappaB dependent transcription
Cheung et al., BMC immunology 2009 : Since MAPK phosphatase-1 (MKP-1) is known to regulate MAPK activities, we examined whether MKP-1 plays a role in BCG induced MAPK activation and cytokine expression ... Additionally, the induction of MKP-1 was regulated by p38 MAPK and extracellular signal regulated kinase 1 and 2 ( ERK1/2 )
Kumabe et al., Microbiol Immunol 2010 : Activation of MAPK is negatively regulated by DUSP , which dephosphorylate the phosphothreonine and phosphotyrosine residues
Horita et al., J Comp Neurol 2010 : Dusp1 is an inactivator of mitogen activated protein kinase ( MAPK ), and MAPK activates expression of egr1, one of the most commonly studied IEGs, as determined in cultured cells
Buzzi et al., Biochim Biophys Acta 2010 (Adenocarcinoma...) : Moreover, ERK1/2 and p38 MAPK are involved in the phosphorylation of MKP-1 in Caco-2 cells
Turpeinen et al., Mediators Inflamm 2011 : Down-regulation of DUSP1 by siRNA increased p38 MAPK phosphorylation and iNOS expression in A549 and J774 cells
Hsu et al., Biochim Biophys Acta 2011 : TSA suppression of JNK and p38MAPK phosphorylation and subsequent COX-2 expression were restored by selective inhibition of MKP-1 using MKP-1 siRNA
Liao et al., Virology 2011 : Meanwhile, IBV has developed a strategy to counteract the induction of IL-6 and IL-8 by inducing the expression of dual-specificity phosphatase 1 (DUSP1) , a negative regulator of the p38 MAPK , in order to limit the production of an excessive amount of IL-6 and IL-8 in the infected cells
Jeanneteau et al., Communicative & integrative biology 2011 : Fine tuning MAPK signaling in the brain : The role of MKP-1
Valente et al., Cell Signal 2012 (Fibrosis...) : Here we show that the proinflammatory cytokine interleukin (IL)-17A induces adult mouse primary cardiac fibroblast ( CF ) proliferation and migration via IL-17 receptor A//IL-17 receptor C-dependent MKP-1 suppression, and activation of p38 MAPK and ERK1/2 ... IL-17A mediated p38 MAPK and ERK1/2 activation is inhibited by MKP-1 overexpression, but prolonged by MKP-1 knockdown
Reuter et al., PloS one 2012 (Inflammation...) : These differences in epithelial restitution were TGF-ß independent but Dex inhibited the EGF/ERK1/2/MAPK-pathway important for intestinal epithelial wound healing by induction of MKP-1 and Annexin-1 which was not affected by CpdA or ZK216348
Li et al., Journal of signal transduction 2012 : MAPK phosphatase-1 (MKP-1) , a negative regulator of MAPK activation, was also critical for periodontal disease progression
Doddareddy et al., Curr Med Chem 2012 : Importantly, there is a strong justification for developing both inhibitors and upregulators of MKP-1 because of the diverse roles played by MAPKs in disease : for example, in cancer, MKP-1 inhibitors may prove beneficial, as MKP-1 is overexpressed and is considered responsible for the failure of JNK-driven apoptotic pathways induced by chemotherapeutics ; conversely, in inflammatory diseases such as asthma and arthritis, MKP-1 reduces MAPK mediated signalling and developing novel ligands to upregulate MKP-1 levels would be a therapeutically attractive anti-inflammatory strategy
Lee et al., Exp Mol Med 2012 (Skin Diseases) : In addition, we found that 12-HHT markedly up-regulates MAPK phosphatase-1 (MKP-1) , a critical negative regulator of p38 MAPK
Leyva-Illades et al., Infect Immun 2012 : Inhibition of p38 MAPK signaling blocked the ability of Stx1 to induce DUSP1 mRNA expression, suggesting that an autoregulatory signaling loop may be activated by Stxs
Che et al., Biochim Biophys Acta 2012 (MAP Kinase Signaling System) : Utilizing the pivotal airway structural cell, airway smooth muscle ( ASM ), we confirm that S1P activates all members of the MAPK family and, in part, S1P upregulates MKP-1 expression in a p38 MAPK dependent manner
Flores et al., J Alzheimers Dis 2012 : These results indicate that TGFß1 induces the expression of MKP-1 in glial cells through the Smad pathway and inhibits MAPK and NF-?B signaling, thus revealing a novel mechanism for the neuroprotective actions of TGFß1
Auger-Messier et al., Circ Res 2013 (Cardiomyopathies...) : Although single nulls showed no molecular effects, combined disruption of Dusp1/4 promoted unrestrained p38 MAPK activity in both mouse embryonic fibroblasts and the heart, with no change in the phosphorylation of c-Jun N-terminal kinases or extracellular signal regulated kinases at baseline or with stress stimulation
Sugimoto et al., J Biol Chem 1996 : MAPK is tightly regulated by the activating kinase, MEK, and specific phosphatase MKP-1 ... In order to understand the mechanism of the anti-proliferative effect of ANP, we examined whether ANP could inhibit MAPK by inducing MKP-1 in cultured rat glomerular mesangial cells
Franklin et al., J Biol Chem 1997 : Conditional expression of the mitogen activated protein kinase ( MAPK ) phosphatase MKP-1 preferentially inhibits p38 MAPK and stress activated protein kinase in U937 cells ... Conditional expression of MKP-1 inhibited PMA induced ERK2, SAPK, and p38 MAPK activity
Franklin et al., Proc Natl Acad Sci U S A 1998 : To determine whether MKP-1 mediated inhibition of SAPK and/or p38 MAPK activity provided cytoprotection against UV-induced apoptosis, a U937 cell line conditionally expressing MKP-1 from the human metallothionein IIa promoter was established
Jeon et al., Biochem Biophys Res Commun 1998 : MKP-1 induced in rat brain after electroconvulsive shock is independent of regulation of 42- and 44-kDa MAPK activity ... MKP-1 induced did not lower the basal level of MAPK activity or attenuate MAPK activation by second ECS