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DNMT1 — STAT3

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: STAT3 — DNMT1 (physical association, affinity chromatography technology) Zhang et al., Proc Natl Acad Sci U S A 2005*
• IRef Biogrid Interaction: STAT3 — DNMT1 (colocalization, imaging technique) Zhang et al., Proc Natl Acad Sci U S A 2005*

Text-mined interactions from Literome

Zhang et al., Blood 2006 (Cell Transformation, Neoplastic...) : STAT3 induces transcription of the DNA methyltransferase 1 gene (DNMT1) in malignant T lymphocytes ... In this study, we demonstrated that STAT3 , a well characterized transcription factor expressed in continuously activated oncogenic form in the large spectrum of cancer types, induces in malignant T lymphocytes the expression of DNMT1 , the key effector of epigenetic gene silencing ... In turn, inhibition of DNMT1 by a small molecule inhibitor, 5-aza-2-deoxy-cytidine, and 2 DNMT1 antisense DNA oligonucleotides inhibits the phosphorylation of STAT3
Ambrogio et al., Cancer Res 2009 (Lymphoma, Large-Cell, Anaplastic) : Finally, NPM-ALK increased the methylation of ZAP70 intron 1-exon 2 boundary region, and both NPM-ALK and STAT3 regulated the expression levels of DNA methyltransferase 1 in transformed T cells
Fukayama et al., Nihon rinsho. Japanese journal of clinical medicine 2012 (Epstein-Barr Virus Infections...) : Viral latent membrane protein 2A (LMP2A) is partly responsible for the promotion of DNA methylation, through STAT3 mediated up-regulation of DNMT1