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CASP5 — DNASE2

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Yokoyama et al., J Biol Chem 2000 : Here, we identified a DNase in Drosophila Schneider cells that can be activated by caspase 3, and purified it as a complex of two subunits ( p32 and p20 )
Luo et al., J Cereb Blood Flow Metab 2002 (Disease Models, Animal...) : Using the in vitro cell-free apoptosis assay, the authors found that caspase-3 dependent deoxyribonuclease activity caused internucleosomal DNA fragmentation in brain-cell extracts in a rat model of transient focal ischemia
Guthrie et al., Reprod Suppl 2001 : The internucleosomal cleavage of genomic DNA caused by caspase induced deoxyribonuclease activity was measured in pig granulosa cells by DNA fluorescence flow cytometry, densitometry of fluorescently labelled internucleosomal DNA fragments and immunohistochemical analysis of the 3 ' end labelling of deoxyribonuclease nicked DNA on frozen tissue sections
Fujikawa et al., J Neurochem 2002 (Disease Models, Animal...) : A caspase-3 activated DNase produces internucleosomal DNA cleavage ( DNA laddering )
Mass et al., Arch Dermatol Res 2003 : Morphometric evaluation of the immunohistochemical data demonstrated that maximal upregulation of P53, DNase I and activation of caspase-3 occurred 12 h after irradiation and in advance of the peak of apoptotic cell death reached after 24 h as verified by ISEL
Xia et al., J Pharmacol Sci 2004 : The drug induced oligonucleosomal fragmentation of DNA in HeLa cells and increased caspase-3, -8, -9 activities followed by the degradation of caspase-3 substrates, inhibitor of caspase dependent DNase , and poly- ( ADP-ribose ) polymerase
Henne et al., Cell Mol Neurobiol 2006 : Data indicate increases in the nuclear levels of caspase activated acinus and DNase and Endonuclease G ( a caspase independent endonuclease ) in CA1 and CA3 PyN nuclei with different temporal patterns following an AMPA-insult
Qi et al., Oncol Rep 2007 (Leukemia, Promyelocytic, Acute) : GP7 induced the release of cytochrome-c from mitochondria, activations of caspase-3 , -8, and -9, cleavage of DFF45/inhibitor of caspase activated DNase, activation of DFF40/caspase activated DNase , and apoptotic DNA fragmentation in NB4 cells
Karmakar et al., Neurochem Res 2007 (Brain Neoplasms...) : Increased caspase-3 activity also cleaved inhibitor of caspase-3 activated DNase and poly ( ADP-ribose ) polymerase
Jana et al., Toxicol In Vitro 2010 : Further, autoschizis is effected through increases in DNase I and DNase II activity with a concomitant decrease in caspase-3 activity which leads to a random cleavage of the DNA as demonstrated by a smear like pattern after electrophoresis on agarose gel