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DCN — IGF1
Text-mined interactions from Literome
Sonal et al., Matrix Biol 2001
:
Prevention of
IGF-1 and TGFbeta
stimulated type II collagen and
decorin expression by bFGF and identification of IGF-1 mRNA transcripts in articular chondrocytes ... the aim of this investigation was to establish whether the action of bFGF modulated the production of type II collagen,
decorin and biglycan
induced by
IGF-1 or TGFbeta in porcine articular chondrocytes ... bFGF prevented the stimulation of type II collagen and
decorin induced in the
presence of
IGF-1 or TGFbeta and up-regulated the production of biglycan in cultured chondrocytes without altering the gene expression of IGF-1
Schaefer et al., Am J Pathol 2007
(Diabetes Mellitus, Type 1...) :
Here, we show that
decorin binds to and
induces phosphorylation of
insulin-like growth factor-I (IGF-I) receptor in renal fibroblasts
Iozzo et al., J Biol Chem 2011
(MAP Kinase Signaling System...) :
However, there are no available data on the
role of
decorin in modulating
IGF-IR activity in transformed cells or in tumor models ...
Decorin bound with high affinity IGF-IR and IGF-I at distinct sites and negatively
regulated IGF-IR activity in urothelial cancer cells ... Notably,
decorin did not
cause down-regulation of the
IGF-IR in bladder, breast, and squamous carcinoma cells ... This indicates that
decorin action on the
IGF-IR differs from its known activity on other receptor tyrosine kinases such as the EGF receptor and Met ... Thus,
decorin loss may
contribute to increased
IGF-IR activity in the progression of bladder cancer and perhaps other forms of cancer where IGF-IR plays a role