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DCN — IGF1

Text-mined interactions from Literome

Sonal et al., Matrix Biol 2001 : Prevention of IGF-1 and TGFbeta stimulated type II collagen and decorin expression by bFGF and identification of IGF-1 mRNA transcripts in articular chondrocytes ... the aim of this investigation was to establish whether the action of bFGF modulated the production of type II collagen, decorin and biglycan induced by IGF-1 or TGFbeta in porcine articular chondrocytes ... bFGF prevented the stimulation of type II collagen and decorin induced in the presence of IGF-1 or TGFbeta and up-regulated the production of biglycan in cultured chondrocytes without altering the gene expression of IGF-1
Schaefer et al., Am J Pathol 2007 (Diabetes Mellitus, Type 1...) : Here, we show that decorin binds to and induces phosphorylation of insulin-like growth factor-I (IGF-I) receptor in renal fibroblasts
Iozzo et al., J Biol Chem 2011 (MAP Kinase Signaling System...) : However, there are no available data on the role of decorin in modulating IGF-IR activity in transformed cells or in tumor models ... Decorin bound with high affinity IGF-IR and IGF-I at distinct sites and negatively regulated IGF-IR activity in urothelial cancer cells ... Notably, decorin did not cause down-regulation of the IGF-IR in bladder, breast, and squamous carcinoma cells ... This indicates that decorin action on the IGF-IR differs from its known activity on other receptor tyrosine kinases such as the EGF receptor and Met ... Thus, decorin loss may contribute to increased IGF-IR activity in the progression of bladder cancer and perhaps other forms of cancer where IGF-IR plays a role