◀ Back to MAP3K5
DAXX — MAP3K5
Pathways - manually collected, often from reviews:
-
BioCarta keratinocyte differentiation:
FAS L/FAS/DAXX/ASK1 complex (FASLG-FAS-DAXX-MAP3K5)
→
JNKK1 (MAP2K4)
(modification, activates)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
FAS/FADD/DAXX/ASK1/Caspase 8/Caspase 8/FAS L complex (FAS-FADD-DAXX-MAP3K5-CASP8-FASLG)
→
Caspase 8/Caspase 8/Caspase 8/Caspase 8 complex (CASP8)
(modification, activates)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
FAS/FADD/DAXX/ASK1/Caspase 8/Caspase 8/FAS L complex (FAS-FADD-DAXX-MAP3K5-CASP8-FASLG)
→
I-FLICE (CFLAR)
(modification, activates)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
TNFSF6 (FASLG)
→
FAS/FADD/DAXX/ASK1/Caspase 8/Caspase 8 complex (FAS-FADD-DAXX-MAP3K5-CASP8)
(modification, collaborate)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
TNFSF6 (FASLG)
→
FAS/FADD/DAXX/ASK1/Caspase 8/Caspase 8/FAS L complex (FAS-FADD-DAXX-MAP3K5-CASP8-FASLG)
(modification, collaborate)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
FAS/FADD/DAXX/ASK1/Caspase 8/Caspase 8 complex (FAS-FADD-DAXX-MAP3K5-CASP8)
→
FAS/FADD/DAXX/ASK1/Caspase 8/Caspase 8/FAS L complex (FAS-FADD-DAXX-MAP3K5-CASP8-FASLG)
(modification, collaborate)
-
BioCarta keratinocyte differentiation:
FAS L/FAS/DAXX/ASK1 complex (FASLG-FAS-DAXX-MAP3K5)
→
MEK3 (MAP2K3)
(modification, activates)
-
BioCarta keratinocyte differentiation:
FAS L/FAS/DAXX/ASK1 complex (FASLG-FAS-DAXX-MAP3K5)
→
MEK6 (MAP2K6)
(modification, activates)
-
BioCarta keratinocyte differentiation:
FAS L/FAS/DAXX/ASK1 complex (FASLG-FAS-DAXX-MAP3K5)
→
FAS L/FAS/DAXX complex (FASLG-FAS-DAXX)
(modification, collaborate)
-
BioCarta keratinocyte differentiation:
FAS L/FAS/DAXX/ASK1 complex (FASLG-FAS-DAXX-MAP3K5)
→
ASK1 (MAP3K5)
(modification, collaborate)
-
BioCarta keratinocyte differentiation:
FAS L/FAS/DAXX complex (FASLG-FAS-DAXX)
→
ASK1 (MAP3K5)
(modification, collaborate)
-
KEGG MAPK signaling pathway:
DAXX
→
MAP3K5
(protein-protein, activation)
-
KEGG Amyotrophic lateral sclerosis (ALS):
DAXX
→
MAP3K5
(protein-protein, activation)
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD)
→
FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8/FASLG complex (FASLG-CASP8-MAP3K5-FAS-DAXX-FADD)
(modification, activates)
Micheau et al., Cell 2003, Yang et al., Cell 1997, Saitoh et al., EMBO J 1998, Chang et al., Science 1998
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
FASLG (FASLG)
→
FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8 complex (FAS-FADD-DAXX-MAP3K5-CASP8)
(modification, collaborate)
Juo et al., Curr Biol 1998
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
FASLG (FASLG)
→
FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8/FASLG complex (FASLG-CASP8-MAP3K5-FAS-DAXX-FADD)
(modification, collaborate)
Juo et al., Curr Biol 1998
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8 complex (FAS-FADD-DAXX-MAP3K5-CASP8)
→
FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8/FASLG complex (FASLG-CASP8-MAP3K5-FAS-DAXX-FADD)
(modification, collaborate)
Juo et al., Curr Biol 1998
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
c-FLIP (CFLAR)
→
FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8/FASLG complex (FASLG-CASP8-MAP3K5-FAS-DAXX-FADD)
(modification, inhibits)
Medema et al., EMBO J 1997
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8/FASLG complex (FASLG-CASP8-MAP3K5-FAS-DAXX-FADD)
→
Caspase 8 (4 units) complex (CASP8)
(modification, activates)
Medema et al., EMBO J 1997
-
WikiPathways Amyotrophic lateral sclerosis (ALS):
DAXX
→
MAP3K5
(activation)
-
WikiPathways Apoptosis Modulation and Signaling:
MAP3K5
→
DAXX
(activation)
-
WikiPathways Apoptosis Modulation and Signaling:
DAXX
→
MAP3K5
(activation)
-
WikiPathways p38 MAPK Signaling Pathway:
TRADD/TRAF2/DAXX/RIPK1
→
MAP3K5
(activation)
-
WikiPathways p38 MAPK Signaling Pathway:
TRADD/TRAF2/DAXX/RIPK1
→
MAP3K5
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
MAP3K5
—
DAXX
(physical association, affinity chromatography technology)
Junn et al., Proc Natl Acad Sci U S A 2005*
-
IRef Biogrid Interaction:
MAP3K5
—
DAXX
(physical association, affinity chromatography technology)
Ko et al., J Biol Chem 2001*
-
IRef Biogrid Interaction:
MAP3K5
—
DAXX
(physical association, affinity chromatography technology)
Charette et al., Mol Cell Biol 2000*
-
IRef Biogrid Interaction:
MAP3K5
—
DAXX
(physical association, affinity chromatography technology)
Song et al., J Cell Biochem 2004*
-
IRef Biogrid Interaction:
MAP3K5
—
DAXX
(physical association, affinity chromatography technology)
Chang et al., Science 1998
-
IRef Biogrid Interaction:
MAP3K5
—
DAXX
(physical association, affinity chromatography technology)
Fukuyo et al., Cancer Res 2009*
-
IRef Hprd Interaction:
MAP3K5
—
DAXX
(in vitro)
Charette et al., Mol Cell Biol 2000*, Chang et al., Science 1998
-
IRef Hprd Interaction:
MAP3K5
—
DAXX
(in vivo)
Charette et al., Mol Cell Biol 2000*, Chang et al., Science 1998
-
IRef Hprd Interaction:
MAP3K5
—
DAXX
(two hybrid)
Charette et al., Mol Cell Biol 2000*, Chang et al., Science 1998
-
IRef Intact Interaction:
MAP3K5
—
DAXX
(physical association, pull down)
Charette et al., Mol Cell Biol 2000*
-
IRef Intact Interaction:
MAP3K5
—
DAXX
(physical association, anti tag coimmunoprecipitation)
Ko et al., J Biol Chem 2001*
-
IRef Intact Interaction:
MAP3K5
—
DAXX
(physical association, anti bait coimmunoprecipitation)
Ko et al., J Biol Chem 2001*
-
IRef Intact Interaction:
MAP3K5
—
DAXX
(colocalization, confocal microscopy)
Ko et al., J Biol Chem 2001*
-
IRef Intact Interaction:
MAP3K5
—
DAXX
(physical association, coimmunoprecipitation)
Chang et al., Science 1998
-
IRef Ophid Interaction:
MAP3K5
—
DAXX
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Charette et al., Mol Cell Biol 2000
:
Here we show that phosphorylated dimers of HSP27 interact with
Daxx , a mediator of Fas induced apoptosis,
preventing the interaction of Daxx with both
Ask1 and Fas and blocking Daxx mediated apoptosis
Junn et al., Proc Natl Acad Sci U S A 2005
(Parkinson Disease) :
Interaction of DJ-1 with
Daxx inhibits
apoptosis signal regulating kinase 1 activity and cell death ... These findings suggest that the regulated sequestration of
Daxx in the nucleus and keeping
apoptosis signal regulating kinase 1 activation in check is a critical mechanism by which DJ-1 exerts its cytoprotective function
Chang et al., Science 1998
:
Activation of
apoptosis signal regulating kinase 1 ( ASK1 ) by the adapter protein
Daxx