Gene interactions and pathways from curated databases and text-mining

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CYP3A — MAPK14

Text-mined interactions from Literome

Fradette et al., Br J Pharmacol 2003 (Anoxia) : The in vitro induction of CYP3A6 by SHYPO is PTK- and p42/44 MAPK dependent
Fradette et al., Curr Drug Metab 2004 (Anoxia...) : The up-regulation of CYP3A6 implies a PTK- and p42/44MAPK dependent stabilization/activation, nuclear translocation of HIF-1 and AP-1, binding to CYP3A6 promoter, and transactivation of the gene to induce CYP3A6 expression