Gene interactions and pathways from curated databases and text-mining

◀ Back to IGF1

CYP19A1 — IGF1

Text-mined interactions from Literome

Silva et al., J Endocrinol 2002 : Insulin and IGF-I are necessary for FSH induced cytochrome P450 aromatase but not cytochrome P450 side-chain cleavage gene expression in oestrogenic bovine granulosa cells in vitro
Kagawa et al., Biol Reprod 2003 : Effects of luteinizing hormone and follicle stimulating hormone and insulin-like growth factor-I on aromatase activity and P450 aromatase gene expression in the ovarian follicles of red seabream, Pagrus major ... Of the growth factors used in the present study, only IGF-I stimulated both aromatase activity and P450arom gene expression in the ovarian fragments of red seabream ... IGF-I slightly enhanced the LH-induced aromatase activity and P450arom gene expression
Ranzenigo et al., Anim Reprod Sci 2008 : ZEA at 3,000 ng/mL inhibited FSH plus IGF-I induced CYP19A1 and CYP11A1 mRNA abundance
Christman et al., Fertil Steril 1991 : The ability of hCG, human FSH, and/or IGF-I to induce aromatase activity was assayed by the stereospecific release of tritium from [ 1B-3H ] androstenedione ... Short-term cultures ( 72 hours ) demonstrated a marked rise in aromatase activity in response to human FSH and IGF-I , whereas a smaller response to hCG was observed
Lueprasitsakul et al., Steroids 1990 : In this tissue, the aromatase activity resides primarily in the stromal cells, and we have used cultures of stromal cells to study the effects of insulin and insulin-like growth factor I (IGF-I) on aromatase activity ... However, insulin ( 100 to 1,000 microU/ml ) and IGF-I ( 500 ng/ml ) markedly attenuated the stimulatory effect of ( Bu ) 2cAMP, but significantly augmented the dexamethasone stimulated aromatase activity
Mani et al., Reproduction 2010 : IGF1 with FSH resulted in a synergistic increase in granulosa cell number and in mRNA expression of CYP19A1 and IGF1R without altering OE(2) production
Paul et al., Mol Cell Endocrinol 2010 : To clarify the mechanism of 17beta-estradiol production by the ovarian follicles during vitellogenic stage of carp, effects of IGF-I and b-insulin either alone or in combination with HCG on aromatase activity ( conversion of testosterone to 17beta-estradiol ) and cytochrome P450 aromatase (P450arom) gene expression were investigated in vitro ... IGF-I and b-insulin alone stimulated aromatase activity and P450arom gene expression and significantly enhanced HCG induced enzyme activity and P450arom gene expression
Bendell et al., Endocrinology 1990 : EGF however inhibited FSH induced and FSH plus IGF-I induced aromatase activity
Spicer et al., Anim Reprod Sci 2011 : RT-PCR measuring abundance of side-chain cleavage enzyme ( CYP11A1 ), aromatase ( CYP19A1 ), FSH receptor (FSHR) and LH receptor ( LHCGR ) mRNA in large- and small-follicle granulosa cells indicated that resistin reduced the stimulatory effect of IGF-I on CPY11A1 mRNA abundance in large-follicle granulosa cells but had no effect on CYP19A1 , FSHR or LHCGR mRNA abundance in large- or small-follicle granulosa cells
Ferrari et al., Int J Oncol 1997 : Effects of aromatase complex selective inhibition on insulin-like growth factor 1 and insulin-like growth factor binding protein 3 circulating levels in breast cancer ... Effects of aromatase complex selective inhibition on insulin-like growth factor 1 and insulin-like growth factor binding protein 3 circulating levels in breast cancer
Sharma et al., Reproduction 2012 : Conjugated linoleic acids attenuate FSH- and IGF1 stimulated cell proliferation ; IGF1, GATA4, and aromatase expression ; and estradiol-17ß production in buffalo granulosa cells involving PPAR?, PTEN, and PI3K/Akt
Reverchon et al., Fertil Steril 2013 (Infertility, Female) : It decreases P and E2 secretion, P450scc and P450 aromatase protein levels, and IGF-IR signaling in response to IGF-I in primary human GCs
Erickson et al., J Clin Endocrinol Metab 1989 : Insulin-like growth factor-I regulates aromatase activity in human granulosa and granulosa luteal cells
Rigaudière et al., Acta Endocrinol (Copenh) 1989 : When related to time ( 0-4 h ) and expressed as percent of control values, aromatase activity in the presence of insulin, IGF-I and/or hCG exhibited a significant and transient increase at 15-30 min
Steinkampf et al., Mol Cell Endocrinol 1988 : Effects of epidermal growth factor and insulin-like growth factor I on the levels of mRNA encoding aromatase cytochrome P-450 of human ovarian granulosa cells ... Insulin-like growth factor I (IGF-I) increased aromatase activity as well as the synthesis of P-450AROM, in a concentration dependent fashion
Nestler et al., Endocrinology 1987 : Because pregnant diabetic women are reported to have lower serum estrogen and higher progesterone concentrations than nondiabetic pregnant women, we studied the roles of insulin and insulin-like growth factor I (IGF-I) in the regulation of human cytotrophoblastic aromatase and P450 side-chain cleavage enzyme ( P450 SCC ) activities ... These studies indicate that insulin exerts a selective inhibitory effect on cytotrophoblastic aromatase activity, whereas IGF-I inhibits aromatase activity but stimulates P450 SCC activity
Hutchinson et al., Mol Cell Endocrinol 1988 : IGF-I also enhanced PMSG induced aromatase activity and progesterone production, and accelerated their peak responses in a similar fashion to the effects observed for GH
Schteingart et al., J Steroid Biochem Mol Biol 1995 : Regulation of Sertoli cell aromatase activity by cell density and prolonged stimulation with FSH, EGF, insulin and IGF-I at different moments of pubertal development
Secreto et al., Anticancer Res 1994 (Breast Neoplasms...) : The elevated testosterone levels and the increased levels of insulin, IGF-I, and IGF-II that are seen in PCOS and abdominal obesity could favor the development of breast cancer in several ways, all of which have been demonstrated experimentally : binding of testosterone to cancer cells bearing testosterone receptors, with direct stimulation ; intratissular aromatization of testosterone to estradiol, with stimulation of estrogen-sensitive cells ; stimulation of the production of epithelial growth factor (EGF) by testosterone, with direct mitogenic effect of EGF on cancer cells ; stimulation of aromatase by insulin and IGF-I ; direct mitogenic stimulation of cancer cells by insulin, IGF-I, and IGF-II ; and stimulation by IGF-I and IGF-II of the intratissular reduction of estrone to estradiol
Costrici et al., Gynecol Endocrinol 1994 : Induction of aromatase in human granulosa cells by both follicle stimulating hormone and insulin-like growth factor-I involves tyrosine phosphorylation ... These findings demonstrate an involvement of a tyrosine kinase pathway in the intracellular signalling mechanism of the IGF-I effect on aromatase activity
Nestler et al., J Steroid Biochem Mol Biol 1993 : Regulation of the aromatase activity of human placental cytotrophoblasts by insulin, insulin-like growth factor-I , and -II ... We will review studies, which show that ( i ) insulin, insulin-like growth factor-I (IGF-I) , and -II inhibit the aromatase activity of human cytotrophoblasts, ( ii ) these peptides can inhibit aromatase by activation of their respective receptors, and ( iii ) the potency of IGF-II in suppressing aromatase greatly exceeds that of either insulin or IGF-I
Rappaport et al., Biol Reprod 1996 : IGF-I inhibited aromatase activity induced by dibutyryl cAMP and inhibited FSH stimulated estrogen production in the presence of 3-isobutyl-1-methylxanthine, suggesting that IGF-I action was independent of cAMP production ... Although IGF-I and PMA both inhibit aromatase induction, the independence of the IGF-I effect from PKC down-regulation suggests that the initial action of IGF-I is independent of PKC
Giudice et al., Prog Growth Factor Res 1995 (Polycystic Ovary Syndrome) : It has been postulated that an inhibitor of IGF 's synergistic actions with FSH on aromatase activity may be one ( or more ) of the IGFBPs, which contributes to the arrested state of follicular development commonly observed in this disorder
Hynes et al., J Reprod Fertil 1996 : FSH and IGF-I , but not EGF, stimulated ( P < 0.01 ) aromatase activity of granulosa cells
Kudoh et al., J Steroid Biochem Mol Biol 1997 (Endometriosis) : Inhibitory effects of a novel aromatase inhibitor, YM511, on growth of endometrial explants and insulin-like growth factor-I gene expression in rats with experimental endometriosis