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CXCR4 — IL12A
Text-mined interactions from Literome
Wan et al., Blood 2004
:
The induction of interferon-gamma-inducible protein 10 ( IP-10 ) secretion by Hsp70L1 is not shared by Hsp70, and other functional differences include more potent stimulation of DC
IL-12p70 , CC-chemokine, and CCR7 and
CXCR4 expression by Hsp70L1. Immunization of mice with the hybrid peptide Hsp70L1-ovalbumin ( OVA ) ( 257-264 )
induces an OVA ( 257-264 ) -specific Th1 response and cytotoxic T lymphocyte ( CTL ) that results in significant inhibition of E.G7-OVA tumor growth
McClymont et al., J Immunol 2011
(Diabetes Mellitus, Type 1) :
Naive Tregs were capable of upregulating expression of Th1 associated T-bet,
CXCR3 , and IFN-? in
response to
IL-12
Galli et al., Eur J Immunol 1998
:
Similarly, in naive CD4+ T cells activated in the presence of IL-4 or IL-12 and infected with the same T-tropic strain, IL-4 up-regulated whereas
IL-12 down-regulated both
CXCR4 and HIV-1 expression ... The down-regulatory
effect of
IL-12 on
CXCR4 expression was found to be dependent on its capacity to induce IFN-gamma production