Gene interactions and pathways from curated databases and text-mining

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AKT1 — CXCR4

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: AKT1 → CXCR4 (increases, CXCR4 Activity, AKT1 Activity)
    Evidence: We used phosphospecific antibodies to Erk1/2 and Akt (protein kinase B) to determine whether these pathways are activated in response to CXCL12 in brain tumor cells. CXCL12 stimulates activation of Erk1/2 and Akt in both medulloblastoma and glioblastoma cells (Fig. 6, which is published as supporting information on the PNAS web site). In both Daoy and U87 cells, these rapid responses to CXCL12 are attenuated by AMD 3100.

Text-mined interactions from Literome

Vlahakis et al., J Immunol 2002 (MAP Kinase Signaling System) : In contrast, Akt activation through CXCR4 by SDF1alpha interactions is necessary to confer resistance to apoptosis
Fukuda et al., Blood 2005 (Acute Disease...) : In contrast, prolonged exposure of CD34+ or Ba/F3-Flt3 cells to FL down-regulated CXCR4 expression, inhibited CXCL12 mediated phosphorylation of MAPK ( p42/p44 ), CREB, and Akt , and impaired migration toward CXCL12
Peng et al., Mol Cancer Res 2005 : The SDF-1alpha induced Akt and ERK1/2 activations are CXCR4 dependent as confirmed by their total inhibition by T134, a CXCR4-specific peptide antagonist
Chinni et al., Prostate 2006 (Bone Neoplasms...) : CXCL12/CXCR4 signaling activates Akt-1 and MMP-9 expression in prostate cancer cells : the role of bone microenvironment associated CXCL12
Zeng et al., Mol Cancer Ther 2006 (Leukemia, Lymphocytic, Chronic, B-Cell...) : Furthermore, RCP168 blocked the binding of anti-CXCR4 monoclonal antibody 12G5 to surface CXCR4 in a concentration dependent manner and inhibited SDF-1alpha induced AKT and extracellular signal regulated kinase phosphorylation
Liang et al., Biochem Biophys Res Commun 2007 (Breast Neoplasms) : Our results showed that CXCR4/CXCL12 induced Akt phosphorylation, which resulted in upregulation of VEGF at both the mRNA and protein levels
Hu et al., Circulation 2007 (Anoxia...) : In isolated myocytes, CXCR4 activation by SDF-1alpha resulted in increased phosphorylation of both ERK 1/2 and AKT and decreased phosphorylation of JNK and p38 ... In isolated myocytes, CXCR4 activation by SDF-1alpha resulted in increased phosphorylation of both ERK 1/2 and AKT and decreased phosphorylation of JNK and p38
Lee et al., Journal of cell communication and signaling 2007 : We also found that CXCR4 induced Akt activation was ROS dependent even though activation of the ERK, JNK, and p38 MAP kinases by CXCR4 occurred via ROS independent pathways ... The differential requirement for ROS in the activation of ERK, JNK, p38, and Akt by the BCR, CD40, and CXCR4 likely reflects the multiplicity of upstream activators for each of these kinases, only some of which may be regulated in a redox dependent manner
Navenot et al., Mol Pharmacol 2009 : We showed previously that the activation of its cognate receptor GPR54 by kisspeptin-10 suppressed the capacity of the prometastatic chemokine receptor CXCR4 to induce chemotaxis in response to stromal cell derived factor 1 and abolished the activation of Akt by CXCR4
Hong et al., Hepatology 2009 (Liver Cirrhosis) : Inhibitor studies suggest that SDF-1alpha/CXCR4 dependent extracellular signal regulated kinase 1/2 and Akt phosphorylation mediate effects on collagen I expression and stellate cell proliferation
Schwartz et al., FEBS Lett 2009 : Finally, MIF stimulated CD74 dependent AKT activation was blocked by anti-CXCR4 and anti-CD74 antibodies and AMD3100, whereas CXCL12 stimulated AKT activation was not reduced by anti-CD74
Oh et al., Biochem Biophys Res Commun 2010 (Myocardial Ischemia) : In addition, SDF-1alpha induced migration and ERK1/2, Akt , and eNOS activation were reduced by AMD3100, a CXCR4-specific peptide antagonist, or by siRNA-CXCR4
Ferretti et al., Leukemia 2011 (Leukemia, Lymphocytic, Chronic, B-Cell) : Akt phosphorylation was involved in CX(3)CL1 induced upregulation of CXCR4 on CLL
Badr et al., PloS one 2011 (Multiple Myeloma) : Activation of CXCR4 by CXCL12 resulted in the association of CXCR4 with CD45 and activation of PLCß3, AKT , RhoA, I?Ba and ERK1/2
Badr et al., PloS one 2012 (Multiple Myeloma) : We found that WEV and WEV+NP clearly decreased the CXCL12/CXCR4 mediated activation of AKT , ERK, NF?B and Rho-A using western blot analysis ; abrogated the CXCL12 mediated proliferation of MM cells using the CFSE assay ; and induced apoptosis in MM cell as determined by PI/annexin V double staining followed by flow cytometry analysis
Heskamp et al., Neurobiol Dis 2013 (Disease Models, Animal...) : Furthermore, the neurite growth promoting and disinhibitory effects of CXCL12 were abrogated by a specific CXCR4 antagonist and by inhibition of the PI3K/AKT/mTOR- , but not the JAK/STAT3-pathway
Esencay et al., BMC cancer 2013 (Glioma...) : Inhibiting CXCR4 in LN229 and LN308 glioma cells that were knocked down for CXCR7 did not further reduce migration towards SDF-1a in hypoxic conditions and did not affect the levels of phosphorylated ERK1/2 and Akt