◀ Back to AKT1
AKT1 — CXCR4
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
AKT1
→
CXCR4
(increases, CXCR4 Activity, AKT1 Activity)
Evidence: We used phosphospecific antibodies to Erk1/2 and Akt (protein kinase B) to determine whether these pathways are activated in response to CXCL12 in brain tumor cells. CXCL12 stimulates activation of Erk1/2 and Akt in both medulloblastoma and glioblastoma cells (Fig. 6, which is published as supporting information on the PNAS web site). In both Daoy and U87 cells, these rapid responses to CXCL12 are attenuated by AMD 3100.
Text-mined interactions from Literome
Vlahakis et al., J Immunol 2002
(MAP Kinase Signaling System) :
In contrast,
Akt activation through
CXCR4 by SDF1alpha interactions is necessary to confer resistance to apoptosis
Fukuda et al., Blood 2005
(Acute Disease...) :
In contrast, prolonged exposure of CD34+ or Ba/F3-Flt3 cells to FL down-regulated
CXCR4 expression,
inhibited CXCL12 mediated phosphorylation of MAPK ( p42/p44 ), CREB, and
Akt , and impaired migration toward CXCL12
Peng et al., Mol Cancer Res 2005
:
The SDF-1alpha induced
Akt and ERK1/2 activations are
CXCR4 dependent as confirmed by their total inhibition by T134, a CXCR4-specific peptide antagonist
Chinni et al., Prostate 2006
(Bone Neoplasms...) :
CXCL12/CXCR4 signaling
activates Akt-1 and MMP-9 expression in prostate cancer cells : the role of bone microenvironment associated CXCL12
Zeng et al., Mol Cancer Ther 2006
(Leukemia, Lymphocytic, Chronic, B-Cell...) :
Furthermore, RCP168 blocked the binding of anti-CXCR4 monoclonal antibody 12G5 to surface
CXCR4 in a concentration dependent manner and
inhibited SDF-1alpha induced
AKT and extracellular signal regulated kinase phosphorylation
Liang et al., Biochem Biophys Res Commun 2007
(Breast Neoplasms) :
Our results showed that
CXCR4/CXCL12 induced
Akt phosphorylation, which resulted in upregulation of VEGF at both the mRNA and protein levels
Hu et al., Circulation 2007
(Anoxia...) :
In isolated myocytes,
CXCR4 activation by SDF-1alpha
resulted in increased phosphorylation of both ERK 1/2 and
AKT and decreased phosphorylation of JNK and p38 ... In isolated myocytes,
CXCR4 activation by SDF-1alpha
resulted in increased phosphorylation of both ERK 1/2 and
AKT and decreased phosphorylation of JNK and p38
Lee et al., Journal of cell communication and signaling 2007
:
We also found that
CXCR4 induced
Akt activation was ROS dependent even though activation of the ERK, JNK, and p38 MAP kinases by CXCR4 occurred via ROS independent pathways ... The differential requirement for ROS in the
activation of ERK, JNK, p38, and
Akt by the BCR, CD40, and
CXCR4 likely reflects the multiplicity of upstream activators for each of these kinases, only some of which may be regulated in a redox dependent manner
Navenot et al., Mol Pharmacol 2009
:
We showed previously that the activation of its cognate receptor GPR54 by kisspeptin-10 suppressed the capacity of the prometastatic chemokine receptor CXCR4 to induce chemotaxis in response to stromal cell derived factor 1 and abolished the
activation of
Akt by
CXCR4
Hong et al., Hepatology 2009
(Liver Cirrhosis) :
Inhibitor studies suggest that
SDF-1alpha/CXCR4 dependent extracellular signal regulated kinase 1/2 and
Akt phosphorylation mediate effects on collagen I expression and stellate cell proliferation
Schwartz et al., FEBS Lett 2009
:
Finally, MIF stimulated CD74 dependent
AKT activation was
blocked by
anti-CXCR4 and anti-CD74 antibodies and AMD3100, whereas CXCL12 stimulated AKT activation was not reduced by anti-CD74
Oh et al., Biochem Biophys Res Commun 2010
(Myocardial Ischemia) :
In addition, SDF-1alpha induced migration and ERK1/2,
Akt , and eNOS activation were
reduced by AMD3100, a CXCR4-specific peptide antagonist, or by
siRNA-CXCR4
Ferretti et al., Leukemia 2011
(Leukemia, Lymphocytic, Chronic, B-Cell) :
Akt phosphorylation was
involved in CX(3)CL1 induced upregulation of
CXCR4 on CLL
Badr et al., PloS one 2011
(Multiple Myeloma) :
Activation of
CXCR4 by CXCL12
resulted in the association of CXCR4 with CD45 and activation of PLCß3,
AKT , RhoA, I?Ba and ERK1/2
Badr et al., PloS one 2012
(Multiple Myeloma) :
We found that WEV and WEV+NP clearly decreased the
CXCL12/CXCR4 mediated
activation of
AKT , ERK, NF?B and Rho-A using western blot analysis ; abrogated the CXCL12 mediated proliferation of MM cells using the CFSE assay ; and induced apoptosis in MM cell as determined by PI/annexin V double staining followed by flow cytometry analysis
Heskamp et al., Neurobiol Dis 2013
(Disease Models, Animal...) :
Furthermore, the neurite growth promoting and disinhibitory effects of CXCL12 were abrogated by a specific
CXCR4 antagonist and by
inhibition of the
PI3K/AKT/mTOR- , but not the JAK/STAT3-pathway
Esencay et al., BMC cancer 2013
(Glioma...) :
Inhibiting
CXCR4 in LN229 and LN308 glioma cells that were knocked down for CXCR7 did not further reduce migration towards SDF-1a in hypoxic conditions and did not
affect the levels of phosphorylated ERK1/2 and
Akt