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CXCR2 — MAPK6
Text-mined interactions from Literome
Venkatakrishnan et al., J Biol Chem 2000
(Ovarian Neoplasms) :
Chemokine receptors
CXCR-1/2 activate
mitogen activated protein kinase via the epidermal growth factor receptor in ovarian cancer cells
Lei et al., Cardiovasc Res 2002
:
OxLDL
upregulates CXCR2 expression in monocytes via scavenger receptors and activation of p38
mitogen activated protein kinase ... Furthermore, p38
MAPK inhibitors SB203580 or SK & F86002 markedly
reduced oxLDL induced
CXCR2 expression
van den Blink et al., J Clin Immunol 2004
(Endotoxemia) :
To investigate the
role of p38 mitogen activated protein kinase (
MAPK ) in the regulation of
CXCR expression during an inflammatory response in vivo, 24 healthy volunteers received an intravenous injection with lipopolysaccharide (LPS) preceded ( -3 hr ) by a specific p38 MAPK inhibitor ( BIRB 796 BS ) at a high dose ( 600 mg ) or a low dose ( 50 mg ) or a placebo