Gene interactions and pathways from curated databases and text-mining

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CXCL8 — TLR4

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: CXCL8 → TLR4 (increases, CXCL8 Activity) Zeuke et al., Cardiovasc Res 2002*
    Evidence: We tested if human coronary artery endothelial cells (HCAEC) may become a source of cytokine and adhesion molecule expression when stimulated with bacterial lipopolysaccharide (LPS). Analysis of HCAEC supernatants by ELISA identified enhanced secretion of IL-6, IL-8, and MCP-1 while
  • OpenBEL Selventa BEL large corpus: CXCL8 → TLR4 (increases, CXCL8 Activity)
    Evidence: Modified assertion