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AKT1 — CXCL16
Text-mined interactions from Literome
Chandrasekar et al., J Biol Chem 2005
:
Src kinase inhibitors PP1 and PP2, phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY294002,
Akt inhibitor, the c-Jun N-terminal kinase (JNK) inhibitor SP600125, antisense JNK and dominant negative MyD88, interleukin-1 receptor associated kinase ( IRAK)-1, IRAK4, and phosphatidylinositol 3-kinase expression all
attenuated IL-18 mediated AP-1 binding and reporter activity,
CXCL16 promoter-reporter activity, and CXCL16 expression
Sai et al., J Biol Chem 2006
:
Although both mutant and wild-type receptors could mediate
Akt and Erk activation in
response to
CXCL8 , the level of activation of these two kinases was much lower in the cell line expressing the mutant receptors
Brkovic et al., J Leukoc Biol 2007
:
Finally, both angiopoietins showed a synergistic effect on the induction of
Akt phosphorylation
mediated by
CXCL8/IL-8
Petrai et al., Int J Biochem Cell Biol 2008
:
In cells expressing CXCR3-A,
CXCL10 ( IP-10 ) at nanomolar concentrations
induced activation of ERK,
Akt , and Src, as previously described in human vascular pericytes
Wang et al., Cancer Res 2008
(Disease Progression...) :
Finally, we found that
CXCL16 signaling
induced the activation of
Akt , p70S6K, and eukaryotic initiation factor 4E binding protein 1 included in mammalian target of rapamycin (mTOR) pathways, which are located downstream of Akt
Hosokawa et al., Clin Exp Immunol 2009
:
CXCL16 treatment
induced HGF proliferation and phosphorylation of extracellular regulated kinase (ERK) and
protein kinase B ( AKT ) in HGF ...
CXCL16 treatment
induced HGF proliferation and phosphorylation of extracellular regulated kinase (ERK) and protein kinase B (
AKT ) in HGF ... In conclusion, HGF expressed CXCR6 functionally, because
CXCL16 induced HGF proliferation and ERK and
AKT phosphorylation in HGF
Diegelmann et al., Inflamm Bowel Dis 2010
(Colitis...) :
CRC expressed CXCR6 was functional, as demonstrated by
CXCL16 induced MAP kinase and
Akt activation
Korniejewska et al., Immunology 2011
:
We report that
CXCL4 induces intracellular calcium mobilization as well as
Akt and p44/p42 extracellular signal regulated kinase phosphorylation, in activated human T lymphocytes
Lin et al., J Biol Chem 2011
:
In this study, we further investigated the
roles of Rac1, phosphoinositide 3-kinase (PI3K), and
Akt in thrombin induced NF-?B activation and
IL-8/CXCL8 expression
Borst et al., Circ Res 2012
(Coronary Artery Disease...) :
CXCL16 increased
Akt phosphorylation ( Thr ( 308 ) /Ser ( 473 ) ), an effect abrogated by phosphatidylinositide 3-kinase inhibitors wortmannin ( 100 nmol/L ) and LY294002 ( 25 µmol/L ) ...
CXCL16 mediated platelet degranulation, integrin a ( IIb ) ß ( 3 ) activation, and
Akt phosphorylation were blunted in platelets lacking CXCL16-specific receptor CXC motif receptor 6
Sahin et al., Hepatology 2013
(Carbon Tetrachloride Poisoning...) :
Specifically,
CXCL10 induced long-term
protein kinase B and Jun N-terminal kinase activation, leading to hepatocyte apoptosis by caspase-8, caspase-3, and p21 activated kinase 2 cleavage
Li et al., Biochem Biophys Res Commun 2012
:
In this study, we first reported that RANKL decreased CXCR6 in a dose dependent manner, which may be through deactivation of
Akt and STAT3 signaling
induced by
CXCL16