Gene interactions and pathways from curated databases and text-mining

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AKT1 — CXCL16

Text-mined interactions from Literome

Chandrasekar et al., J Biol Chem 2005 : Src kinase inhibitors PP1 and PP2, phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY294002, Akt inhibitor, the c-Jun N-terminal kinase (JNK) inhibitor SP600125, antisense JNK and dominant negative MyD88, interleukin-1 receptor associated kinase ( IRAK)-1, IRAK4, and phosphatidylinositol 3-kinase expression all attenuated IL-18 mediated AP-1 binding and reporter activity, CXCL16 promoter-reporter activity, and CXCL16 expression
Sai et al., J Biol Chem 2006 : Although both mutant and wild-type receptors could mediate Akt and Erk activation in response to CXCL8 , the level of activation of these two kinases was much lower in the cell line expressing the mutant receptors
Brkovic et al., J Leukoc Biol 2007 : Finally, both angiopoietins showed a synergistic effect on the induction of Akt phosphorylation mediated by CXCL8/IL-8
Petrai et al., Int J Biochem Cell Biol 2008 : In cells expressing CXCR3-A, CXCL10 ( IP-10 ) at nanomolar concentrations induced activation of ERK, Akt , and Src, as previously described in human vascular pericytes
Wang et al., Cancer Res 2008 (Disease Progression...) : Finally, we found that CXCL16 signaling induced the activation of Akt , p70S6K, and eukaryotic initiation factor 4E binding protein 1 included in mammalian target of rapamycin (mTOR) pathways, which are located downstream of Akt
Hosokawa et al., Clin Exp Immunol 2009 : CXCL16 treatment induced HGF proliferation and phosphorylation of extracellular regulated kinase (ERK) and protein kinase B ( AKT ) in HGF ... CXCL16 treatment induced HGF proliferation and phosphorylation of extracellular regulated kinase (ERK) and protein kinase B ( AKT ) in HGF ... In conclusion, HGF expressed CXCR6 functionally, because CXCL16 induced HGF proliferation and ERK and AKT phosphorylation in HGF
Diegelmann et al., Inflamm Bowel Dis 2010 (Colitis...) : CRC expressed CXCR6 was functional, as demonstrated by CXCL16 induced MAP kinase and Akt activation
Korniejewska et al., Immunology 2011 : We report that CXCL4 induces intracellular calcium mobilization as well as Akt and p44/p42 extracellular signal regulated kinase phosphorylation, in activated human T lymphocytes
Lin et al., J Biol Chem 2011 : In this study, we further investigated the roles of Rac1, phosphoinositide 3-kinase (PI3K), and Akt in thrombin induced NF-?B activation and IL-8/CXCL8 expression
Borst et al., Circ Res 2012 (Coronary Artery Disease...) : CXCL16 increased Akt phosphorylation ( Thr ( 308 ) /Ser ( 473 ) ), an effect abrogated by phosphatidylinositide 3-kinase inhibitors wortmannin ( 100 nmol/L ) and LY294002 ( 25 µmol/L ) ... CXCL16 mediated platelet degranulation, integrin a ( IIb ) ß ( 3 ) activation, and Akt phosphorylation were blunted in platelets lacking CXCL16-specific receptor CXC motif receptor 6
Sahin et al., Hepatology 2013 (Carbon Tetrachloride Poisoning...) : Specifically, CXCL10 induced long-term protein kinase B and Jun N-terminal kinase activation, leading to hepatocyte apoptosis by caspase-8, caspase-3, and p21 activated kinase 2 cleavage
Li et al., Biochem Biophys Res Commun 2012 : In this study, we first reported that RANKL decreased CXCR6 in a dose dependent manner, which may be through deactivation of Akt and STAT3 signaling induced by CXCL16