◀ Back to MAPK3
CXCL12 — MAPK3
Pathways - manually collected, often from reviews:
-
BioCarta role of ß-arrestins in the activation and targeting of map kinases:
Ligand/GPCR(+)/Arrestin/RAF1/MEK1/MEK2/ERK1/ERK2 complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1-RAF1-MAP2K1-MAP2K2-MAPK3-MAPK1)
→
MEK2 (MAP2K2)
(modification, collaborate)
-
BioCarta role of ß-arrestins in the activation and targeting of map kinases:
Ligand/GPCR(+)/Arrestin/RAF1/MEK1/MEK2/ERK1/ERK2 complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1-RAF1-MAP2K1-MAP2K2-MAPK3-MAPK1)
→
RAF1
(modification, collaborate)
-
BioCarta role of ß-arrestins in the activation and targeting of map kinases:
Ligand/GPCR(+)/Arrestin/RAF1/MEK1/MEK2/ERK1/ERK2 complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1-RAF1-MAP2K1-MAP2K2-MAPK3-MAPK1)
→
ERK2 (MAPK1)
(modification, collaborate)
-
BioCarta role of ß-arrestins in the activation and targeting of map kinases:
Ligand/GPCR(+)/Arrestin/RAF1/MEK1/MEK2/ERK1/ERK2 complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1-RAF1-MAP2K1-MAP2K2-MAPK3-MAPK1)
→
Ligand/GPCR(+)/Arrestin complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1)
(modification, collaborate)
-
BioCarta role of ß-arrestins in the activation and targeting of map kinases:
Ligand/GPCR(+)/Arrestin/RAF1/MEK1/MEK2/ERK1/ERK2 complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1-RAF1-MAP2K1-MAP2K2-MAPK3-MAPK1)
→
MEK1 (MAP2K1)
(modification, collaborate)
-
BioCarta role of ß-arrestins in the activation and targeting of map kinases:
Ligand/GPCR(+)/Arrestin/RAF1/MEK1/MEK2/ERK1/ERK2 complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1-RAF1-MAP2K1-MAP2K2-MAPK3-MAPK1)
→
ERK1 (MAPK3)
(modification, collaborate)
-
BioCarta role of ß-arrestins in the activation and targeting of map kinases:
Ligand/GPCR(+)/Arrestin complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1)
→
ERK1 (MAPK3)
(modification, collaborate)
-
BioCarta role of ß-arrestins in the activation and targeting of map kinases:
Ligand/GPCR(+)/Arrestin/RAF1/MEK1/MEK2/ERK1/ERK2 complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1-RAF1-MAP2K1-MAP2K2-MAPK3-MAPK1)
→
dynamin gtpase (DNM1)
(translocation, collaborate)
-
BioCarta role of ß-arrestins in the activation and targeting of map kinases:
Ligand/GPCR(+)/Arrestin/RAF1/MEK1/MEK2/ERK1/ERK2 complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1-RAF1-MAP2K1-MAP2K2-MAPK3-MAPK1)
→
Ligand/GPCR(+)/Arrestin/RAF1/MEK1/MEK2/ERK1/ERK2(cy) complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1-RAF1-MAP2K1-MAP2K2-MAPK3-MAPK1)
(translocation, collaborate)
-
BioCarta role of ß-arrestins in the activation and targeting of map kinases:
dynamin gtpase (DNM1)
→
Ligand/GPCR(+)/Arrestin/RAF1/MEK1/MEK2/ERK1/ERK2(cy) complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1-RAF1-MAP2K1-MAP2K2-MAPK3-MAPK1)
(translocation, activates)
Text-mined interactions from Literome
Sotsios et al., J Immunol 1999
:
Finally,
SDF-1 stimulated extracellular signal related kinase ( ERK)-1/2
mitogen activated protein kinase activation was inhibited by PI 3-kinase inhibitors ... Finally,
SDF-1 stimulated extracellular signal related kinase (
ERK)-1/2 mitogen activated protein kinase activation was inhibited by PI 3-kinase inhibitors
Majka et al., Eur J Haematol 2000
(Leukemia-Lymphoma, Adult T-Cell) :
We found that stimulation of these cells with
SDF-1alpha led to the phosphorylation of
MAPK and serine/threonine kinase AKT as well
Montes et al., Eur Cytokine Netw 2000
:
SDF-1 activates
ERK-1 and ERK-2 in Jurkat cells
Honczarenko et al., Blood 2002
:
This cross-desensitization of CXCR4 was manifested by the inhibition of
CXCL12 induced calcium mobilization,
MAPK activation, and chemotaxis
Ratajczak et al., Stem Cells 2003
:
These cell lines responded to
SDF-1 stimulation by chemotaxis, phosphorylation of
mitogen activated protein kinase ( MAPK ) p42/44 and AKT serine-threonine kinase, and calcium flux, confirming the functionality of the CXCR4 receptor
Kayali et al., J Cell Biol 2003
(Disease Models, Animal) :
We show that
SDF-1alpha stimulates the phosphorylation of Akt,
mitogen activated protein kinase , and Src in pancreatic duct cells
Ottonello et al., Cell Signal 2005
:
When the
activation of ERK-1/2 and p38
MAPK by CCL3 and the classical neutrophilic chemokine
CXCL8 ( IL-8 ) were compared, both the chemokines were capable of activating p38 MAPK ... When the
activation of
ERK-1/2 and p38 MAPK by CCL3 and the classical neutrophilic chemokine
CXCL8 ( IL-8 ) were compared, both the chemokines were capable of activating p38 MAPK ... On the contrary, whereas both
ERK-1 and ERK-2 were
activated by
CXCL8 , no ERK-1 band was detectable after CCL3 triggering
Fukuda et al., Blood 2005
(Acute Disease...) :
In contrast, prolonged exposure of CD34+ or Ba/F3-Flt3 cells to FL down-regulated CXCR4 expression, inhibited
CXCL12 mediated phosphorylation of
MAPK ( p42/p44 ), CREB, and Akt, and impaired migration toward CXCL12
Katayama et al., Clin Cancer Res 2005
(Carcinoma, Squamous Cell...) :
SDF-1 also
promoted rapid phosphorylation of
extracellular signal regulated kinase 1/2 and Akt signaling pathways in CXCR4 positive cells
Méndez-Samperio et al., Cell Immunol 2005
(MAP Kinase Signaling System) :
Our data also demonstrate that M. bovis BCG induced
CXC chemokine ligand ( CXCL ) 8 release in epithelial cells was
reduced by a mitogen activated protein/ERK kinase ( MEK ) inhibitor ( PD98059 ), but not by a p38
MAPK ( SB203580 ) inhibitor
Berthebaud et al., Blood 2005
:
Overexpressing RGS16 mRNA in the megakaryocytic MO7e cell line inhibited
SDF-1 induced migration,
mitogen activated protein kinase ( MAPK ) and protein kinase B ( AKT ) activation, whereas RGS18 overexpression had no effect on CXCR4 signaling
Brand et al., Exp Cell Res 2005
(Colorectal Neoplasms...) :
CXCL12 activates
ERK-1/2 , SAPK/JNK kinases, Akt and matrix metalloproteinase-9
Rousseau et al., Cell Signal 2006
(MAP Kinase Signaling System) :
Here we show that
CXCL12 , complement factor 5a ( C5a ), hepatocyte growth factor (HGF) and platelet derived growth factor (PDGF)-BB, which stimulate cell migration, also
activate p38alpha
MAPK ... We also show that the activation of p38alpha
MAPK in
response to
CXCL12 requires the p21 activated protein kinases (PAK)-1 and PAK-2
Scala et al., Clin Cancer Res 2006
(Melanoma) :
Other chemokine receptors, CCR7 and CCR10, were detected on the melanoma cell lines
; CXCL12 activated
Erk-1 and Erk-2, the whose induction was specifically inhibited by AMD3100 treatment
Lane et al., Int Immunol 2006
:
However, wild-type Cbl or its mutants had no effect on the
CXCL8 induced activation of
MAPK , indicating that Cbl specifically modulated CXCL8 induced chemotaxis
Feng et al., J Immunol 2006
(Calcium Signaling) :
hBD-3 competes with stromal derived factor 1 (SDF-1), the natural ligand for CXCR4, for cellular binding and blocks
SDF-1 induced calcium flux,
ERK-1/2 phosphorylation, and chemotaxis, without effects on other G protein coupled receptors
Wei et al., J Rheumatol 2006
(Arthritis) :
SDF-1 stimulated p38
MAPK activity in a dose- and time dependent manner
Amin et al., Arthritis Rheum 2007
(Arthritis, Rheumatoid) :
IL-18 induced
SDF-1alpha/CXCL12 up-regulation was
dependent on JNK, p38
MAPK , phosphatidylinositol 3-kinase (PI3K), and NFkappaB
Hu et al., Circulation 2007
(Anoxia...) :
In isolated myocytes, CXCR4 activation by
SDF-1alpha resulted in increased phosphorylation of both
ERK 1/2 and AKT and decreased phosphorylation of JNK and p38
Petrai et al., Int J Biochem Cell Biol 2008
:
In human microvascular endothelial cells, which selectively express CXCR3-B, in a cell cycle dependent fashion,
CXCL10 and CXCL4
increased the enzymatic activity of p38 (
MAPK )
Gouwy et al., Mol Pharmacol 2008
:
It is noteworthy that CCL2 mediated
extracellular signal regulated kinase 1/2 phosphorylation and calcium mobilization was significantly
enhanced by
CXCL8 in monocytes, indicating cooperative downstream signaling pathways during enhanced chemotaxis
Proost et al., J Exp Med 2008
(Autoimmune Diseases...) :
In comparison with CXCL8 ( 1-77 ),
CXCL8 ( 1-77 ) Cit ( 5 ) had reduced affinity for glycosaminoglycans and
induced less CXCR2 dependent calcium signaling and
extracellular signal regulated kinase 1/2 phosphorylation
Lee et al., Int J Oncol 2009
(Adenocarcinoma...) :
SDF-1alpha induced rapid phosphorylation of Erk1/2
MAPK but did not promote phosphorylation of Stat3 or Akt
Friedrich et al., Basic Res Cardiol 2009
(Coronary Artery Disease) :
Our goal was to examine the
regulation of
ERK-1/2 by
SDF-1 and the role of ERK-1/2 for adhesion in EPCs
Hong et al., Hepatology 2009
(Liver Cirrhosis) :
Inhibitor studies suggest that
SDF-1alpha/CXCR4 dependent
extracellular signal regulated kinase 1/2 and Akt phosphorylation mediate effects on collagen I expression and stellate cell proliferation
Gaundar et al., Cell cycle (Georgetown, Tex.) 2009
(Precursor Cell Lymphoblastic Leukemia-Lymphoma) :
We have demonstrated that inhibition of p38 (
MAPK ) in bone marrow stromal cells
reduced the production of IL-6, VEGF, PDGF and
CXCL12
Rahimi et al., Int J Cancer 2010
(Breast Neoplasms...) :
We also demonstrate that p38 MAPK is one of the major down-stream signaling molecules responsible for EGFRvIII/CXCR4 mediated invasion as p38
MAPK activity was
induced by
CXCL12 stimulation under both normoxic and hypoxic conditions
Hattermann et al., Cancer Res 2010
(Brain Neoplasms...) :
Stimulation of CXCR7 positive glioma cells ( CXCR4- and CXCR3 negative ) by
CXCL12 induced transient phosphorylation of extracellular signal regulated kinases
Erk1/2 , indicating that the receptor is functionally active
Song et al., Exp Mol Med 2010
(Pulmonary Fibrosis) :
In BM stem cell experiments, the phosphorylation of p38
MAPK which was
induced by
SDF-1 was significantly blocked by addition of AMD3100
Cao et al., Microbes Infect 2010
(Pneumococcal Infections) :
Both PspA and PspC could activate p38 MAPK and NF-?B pathways in neutrophils, while inhibition of NF-?B and p38
MAPK could
suppress the release of
CXCL8 from neutrophils induced by PspA and PspC. Together, our results demonstrated that the induction of CXCL8 in human neutrophils activated by PspA and PspC was regulated by p38 MAPK and NF-?B pathways
Dogan et al., Microbes Infect 2011
:
Pneumolysin induced
CXCL8 production by nasopharyngeal epithelial cells is
dependent on calcium flux and
MAPK activation via Toll-like receptor 4
Kremer et al., J Immunol 2011
(Calcium Signaling...) :
The CXCR4-TCR heterodimer stimulates T cell migration and activation of the ERK
MAPK and downstream AP-1 dependent cytokine transcription in
response to
stromal cell derived factor-1 (SDF-1) , the sole chemokine ligand of CXCR4
Chen et al., Molecular vision 2011
:
Inhibition of
p38MAPK , phosphoinositide 3-kinase (PI3K)-Akt and nuclear factor-kappaB ( NF-?B ), with the inhibitors SB203580, LY294002 and pyrrolydine dithiocarbamate ( PDTC ) respectively,
reduced IL-17 ( 100 ng/ml ) mediated production of
CXCL8 , CCL2, and IL-6 in a concentration dependent manner
Dumitru et al., J Leukoc Biol 2012
(Head and Neck Neoplasms...) :
Most importantly, HNC induced
p38-MAPK activation strongly
stimulates the release of CCL4,
CXCL8 , and MMP9 by neutrophils
Du et al., Hum Reprod 2012
:
CsA
up-regulated CXCL12 and CXCR4 expression in human first-trimester cytotrophoblast cells, but not in DSCs. Blocking the mitogen activated proteinkinase/extracellular signal regulated kinase (
MAPK/ERK1/2 ) signaling by U0126 abrogated the CsA induced increase in CXCL12 and CXCR4 expression and neutralizing antibodies to CXCL12 or CXCR4 completely inhibited the CsA induced increase in cell number, invasion and MMP-9 and MMP-2 activity of cytotrophoblast
Li et al., Am J Transplant 2012
(Arteriosclerosis) :
Conditioned media from Ltv-p53 transferred SMCs activated PI3K/Akt/mTOR and
MAPK/Erk signaling in a
SDF-1a dependent manner and thereby promoted mesenchymal stem cell (MSC) migration and proliferation
Blume et al., Eur Respir J 2013
(Asthma...) :
Inhibition of the
extracellular signal regulated kinase 1/2 and p38 mitogen activated protein kinase pathways selectively
blocked apical
CXCL8/IL-8 release via a post-transcriptional mechanism
Zhao et al., Diabetes 2013
(Diabetes Mellitus, Experimental) :
SDF-1ß receptor C-X-C chemokine receptor type 4 (CXCR4) antagonist AMD3100 or CXCR4 small interfering RNA could not, but CXCR7 small interfering RNA completely abolished
SDF-1ß 's protection from palmitate induced apoptosis and
activation of AMPK and p38
MAPK
Meisch et al., J Leukoc Biol 2013
(MAP Kinase Signaling System) :
In contrast, hBD-3 was reported to neutralize the activation of T cells by antagonizing
MAPK signaling
initiated by
SDF-1a through CXCR4