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CXCL12 — HIF1A

Pathways - manually collected, often from reviews:

• NCI Pathway Database HIF-1-alpha transcription factor network: HIF1A/ARNT complex (HIF1A-ARNT) → SDF1 (CXCL12) (transcription, activates) Ceradini et al., Nat Med 2004*
  Evidence: mutant phenotype, reporter gene, physical interaction

Text-mined interactions from Literome

Tabatabai et al., Brain 2006 (Brain Neoplasms...) : Irradiation and hypoxia promote homing of haematopoietic progenitor cells towards gliomas by TGF-beta dependent HIF-1alpha mediated induction of CXCL12
Nemenoff et al., Circ Res 2008 (Hyperplasia...) : SDF-1alpha production by other cell types is regulated by the transcription factor hypoxia-inducible factor (HIF)-1alpha ... We found SMC nuclear HIF-1alpha expression in PTEN depleted mice and increased nuclear HIF-1alpha in PTEN-deficient SMCs. Small interfering RNA mediated downregulation of HIF-1alpha reversed SDF-1alpha induction by PTEN depletion and inhibition of phosphatidylinositol 3-kinase signaling blocked HIF-1alpha and SDF-1alpha upregulation induced by PTEN depletion