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CTGF — MAPK3
Text-mined interactions from Literome
Yosimichi et al., Eur J Biochem 2001
:
In the proliferation phase,
CTGF/Hcs24 induced a approximately fivefold increase in the phosphorylation of p44/42
MAPK/ERK and a approximately twofold increase in that of p38 MAPK in an in vivo kinase assay
Sohn et al., Kidney Int 2005
:
Inhibition of p38 ( mapk ) or
p42/44(mapk) activities did not
affect LDL induced TGF-beta1,
CTGF , and collagen I expression, whereas inhibition of c-Jun NH2-terminal kinase (JNK) suppressed LDL induced TGF-beta, CTGF, and collagen I expression
Liu et al., J Cell Biochem 2006
:
Inhibitors of ERK1/2 and JNK but not
p38MAPK inhibited the BK- and AngII stimulated expression of
CTGF in cells expressing either the WT or mutant receptors, illustrating that ERK and JNK participate in the control of CTGF expression in a manner that appears to be independent of G-protein
Mulsow et al., Ann Surg 2005
(Crohn Disease...) :
ERK 1/2 inhibition
had a similar effect on TGF-beta induced
CTGF and fibronectin expression
Wu et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2006
:
CTGF increased the
p42/44MAPK phosphorylation ... Pretreatment of the cells with PD98059 or UO126, inhibitors of phosphorylated p42/44 MAKP, decreased the
CTGF induced expression of phosphorylated p42/44
MAPK and concentration of FLK in supernatants
Wu et al., Kidney Int 2006
:
CTGF enhanced the mRNA expression and protein release of fractalkine, MCP-1, and RANTES, the expression of phospho ( P ) -p42/44
mitogen activated protein kinase ( MAPK ), P-phosphoinositide 3-kinase (PI3-K), P-Akt, and activity of nuclear factor-kappaB (NF-kappaB) in mesangial cells ... P-p42/44 MAPK blockade inhibited the
CTGF induced expression of P-p42/44
MAPK but not NF-kappaB, and partially decreased the levels of the above chemokines in supernatants ... P-PI3-K blockade downregulated the
CTGF stimulated expression of P-PI3-K, P-Akt, and NF-kappaB but not P-p42/44
MAPK , and partially decreased the release of the above chemokines ... LXA ( 4 ) dose-dependently inhibited the
CTGF stimulated mRNA expression and protein release of the above chemokines, and the expression of
P-p42/44MAPK , P-PI3-K, P-Akt, and NF-kappaB
Chien et al., Mol Cancer Res 2006
(Carcinoma, Non-Small-Cell Lung...) :
Most interestingly, overexpression of
CTGF suppressed insulin-like growth factor-I dependent Akt phosphorylation and epidermal growth factor dependent
extracellular signal regulated kinase 1/2 phosphorylation
Hong et al., J Cell Biochem 2007
(Diabetes Mellitus, Type 2...) :
Glucose and insulin induced
ERK 1/2 phosphorylation also
stimulated connective tissue growth factor gene expression
Bogatkevich et al., Arthritis Rheum 2007
(MAP Kinase Signaling System...) :
The
MAPK inhibitor, U0126, blocked MMP-1 activity and
restored HGF inhibited collagen and
CTGF accumulation
Kanno et al., Am J Pathol 2010
(Disease Progression...) :
Moreover, we found that
connective tissue growth factor induced the expression of alpha2AP through both the
extracellular signal regulated kinase 1/2 ( ERK1/2 ) and c-Jun N-terminal kinase (JNK) pathways in fibroblasts
Browne et al., Invest Ophthalmol Vis Sci 2011
(Exfoliation Syndrome...) :
Western blot analysis demonstrated increased phosphorylation of p42/44 MAPK, p38
MAPK , and the JNK pathways in
response to
CTGF
Guo et al., Chin Med J (Engl) 2010
(Fibrosis...) :
The effects of the protein kinase A (PKA) activator 8-Br-cAMP and protein kinase C ( PKC ) activator phorbol 12-myristate 13-acetate ( PMA ) on
MAPK phosphorylation, and the
effects of the PKA inhibitor H89 and PKC inhibitor calphostin C on MAPK phosphorylation and
CTGF expression were detected by immunoblotting assay
Ding et al., Cell Signal 2013
:
Taken together, our results provide evidence for the role of HPCs in liver fibrosis and suggest that the production of
CTGF by TGF-ß
activated MAPK signaling in HPCs may be a therapeutic target of liver fibrosis