◀ Back to IGF1

CTGF — IGF1

Text-mined interactions from Literome

Wang et al., Kidney Int 2001 (Diabetes Mellitus, Experimental...) : In NRK-49F cells, IGF-I increased the activity of CTGF towards the expression of Col alpha1III
Strammiello et al., Horm Metab Res 2003 (Bone Neoplasms...) : IGF-I increases expression of VEGF-A, TGFbeta, CTGF and Cyr61 mRNA
Zhou et al., Domest Anim Endocrinol 2008 : Administration of growth hormone (GH), a strong stimulator of IGF1 production in vivo, decreased mammary CTGF mRNA in cattle ; however, GH did not affect CTGF expression in MAC-T cells, suggesting that IGF1 may also inhibit CTGF expression in the mammary gland ... Added alone CTGF stimulated proliferation of MAC-T cells, but in combination with IGF1 it attenuated IGF1 's stimulation of proliferation of MAC-T cells ... Despite being an IGF binding protein, CTGF did not affect IGF1 induced phosphorylation of IGF1 receptor (IGF1R) or IGF1R expression in MAC-T cells, indicating that the attenuating effect of CTGF on IGF1 stimulated proliferation of MAC-T cells was not mediated by decreasing IGF1 's ability to bind to IGF1R or by decreasing IGF1R expression ... Overall, these results suggest a novel biochemical and functional relationship between CTGF and IGF1 in the bovine mammary gland, where IGF1 may inhibit CTGF expression to reduce the attenuating effect of CTGF on IGF1 stimulated proliferation of epithelial cells
Tomita et al., PloS one 2013 : Cartilage-specific over-expression of CCN family member 2/connective tissue growth factor ( CCN2/CTGF ) stimulates insulin-like growth factor expression and bone growth
Tamatani et al., Biochem Biophys Res Commun 1998 (Biliary Atresia...) : By using the ELISA, we confirmed that CTGF was specifically induced in human fibroblasts by TGF-beta but not by PDGF, FGF, IGF-I , or EGF