Gene interactions and pathways from curated databases and text-mining

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CTCF — IGF2

Text-mined interactions from Literome

Yang et al., J Cell Biochem 2003 : In this study, we examined the allelic DNA methylation and CTCF binding in the Igf2/H19 imprinting center in CNS, hypothesizing that the aberrant CTCF binding as one of the mechanisms leads to biallelic expression of Igf2 in CNS
Fu et al., J Biol Chem 2004 : The forced down-regulation of CTCF expression using small interfering RNA in imprinted prostate cell lines resulted in an increase in IGF2 expression and a relaxation of imprinting
Kurukuti et al., Proc Natl Acad Sci U S A 2006 : CTCF binding in the maternal ICR regulates its interaction with matrix attachment region ( MAR ) 3 and DMR1 at Igf2 , thus forming a tight loop around the maternal Igf2 locus, which may contribute to its silencing
Li et al., Mol Cell Biol 2008 : CTCF regulates allelic expression of Igf2 by orchestrating a promoter-polycomb repressive complex 2 intrachromosomal loop
Zhang et al., J Cell Biol 2011 : Monoallelic expression of IGF2 is regulated by CCCTC binding factor (CTCF) binding to the imprinting control region ( ICR ) on the maternal allele, with subsequent formation of an intrachromosomal loop to the promoter region