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CSRP1 — NOS1
Text-mined interactions from Literome
Sjöholm et al., Lancet 2005
(Arteriosclerosis...) :
Subodh Verma and associates ( Circulation 2004 ; 109 : 2058-67 ) recently showed that CRP attenuates the survival, differentiation, and function of endothelial progenitor cells, partly by
CRP reducing expression of endothelial
nitric-oxide synthase
Riba et al., Thromb Haemost 2005
:
Thus the mechanisms of collagen- and
CRP-XL induced
NOS activation were identical, but distinct from that of thrombin
Xu et al., Mol Endocrinol 2007
(Insulin Resistance...) :
Recombinant
CRP suppressed insulin induced NO production,
inhibited the phosphorylation of Akt and endothelial
nitric oxide synthase , and stimulated the phosphorylation of IRS-1 at the Ser307 site in a dose dependent manner
Ma et al., Zhong Nan Da Xue Xue Bao Yi Xue Ban 2009
(Acute Coronary Syndrome) :
NOS , NO, and FMD in the 2 groups 24 hours after the PCI were significantly lower than those before the PCI ( P < 0.05 ), but hs-
CRP obviously
increased ( P < 0.05 )
Tanigaki et al., Diabetes 2013
(Insulin Resistance) :
CRP does not
impair skeletal muscle glucose delivery in Fc?RIIB ( -/- ) mice or in endothelial
nitric oxide synthase knock-in mice with phosphomimetic modification of Ser1176, which is normally phosphorylated by insulin signaling to stimulate nitric oxide mediated skeletal muscle blood flow and glucose delivery and is dephosphorylated by CRP/Fc?RIIB