Gene interactions and pathways from curated databases and text-mining

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CSRP1 — NOS1

Text-mined interactions from Literome

Sjöholm et al., Lancet 2005 (Arteriosclerosis...) : Subodh Verma and associates ( Circulation 2004 ; 109 : 2058-67 ) recently showed that CRP attenuates the survival, differentiation, and function of endothelial progenitor cells, partly by CRP reducing expression of endothelial nitric-oxide synthase
Riba et al., Thromb Haemost 2005 : Thus the mechanisms of collagen- and CRP-XL induced NOS activation were identical, but distinct from that of thrombin
Xu et al., Mol Endocrinol 2007 (Insulin Resistance...) : Recombinant CRP suppressed insulin induced NO production, inhibited the phosphorylation of Akt and endothelial nitric oxide synthase , and stimulated the phosphorylation of IRS-1 at the Ser307 site in a dose dependent manner
Ma et al., Zhong Nan Da Xue Xue Bao Yi Xue Ban 2009 (Acute Coronary Syndrome) : NOS , NO, and FMD in the 2 groups 24 hours after the PCI were significantly lower than those before the PCI ( P < 0.05 ), but hs- CRP obviously increased ( P < 0.05 )
Tanigaki et al., Diabetes 2013 (Insulin Resistance) : CRP does not impair skeletal muscle glucose delivery in Fc?RIIB ( -/- ) mice or in endothelial nitric oxide synthase knock-in mice with phosphomimetic modification of Ser1176, which is normally phosphorylated by insulin signaling to stimulate nitric oxide mediated skeletal muscle blood flow and glucose delivery and is dephosphorylated by CRP/Fc?RIIB