Okamura et al., Life Sci 2006
:
Contrary to KN-CKIepsilon, WT-CKIepsilon attenuated the IL-3 induced activation of Akt with the increase of PTEN activity ... These results suggest that the CKIepsilon induced down-regulation of PI3K/Akt signaling through PTEN lead to amplified sensitivity to apoptosis
Modak et al., Biochem Biophys Res Commun 2008
(Breast Neoplasms) :
Conversely, we show that a CKIepsilon/delta-specific inhibitor can inhibit Akt phosphorylation at both Thr308 and Ser473 and drastically reduce phosphorylation of the Akt target Glycogen Synthase Kinase 3beta ( GSK3beta ) ... Here we propose that, rather than inhibiting PTEN function, CKIepsilon positively regulates Akt possibly by inhibiting Protein Phosphatase 2A (PP2A)
Leonard et al., Cell cycle (Georgetown, Tex.) 2013
:
Inhibition of Akt activation with MK2206 reduced the whole-cell and centrosome levels of PLK-1 and ?-tubulin and also prevented the recruitment of PTEN to mitotic centrosomes