Hagen et al., Biochem Biophys Res Commun 2002
:
Ser45 phosphorylation in intact cells is not mediated by CK1varepsilon , a known positive regulator of Wnt signalling, as overexpression of this kinase leads to decreased phosphorylation levels
Casagolda et al., J Cell Sci 2010
:
A p120-catenin-CK1epsilon complex regulates Wnt signaling
Cruciat et al., Science 2013
(Wnt Signaling Pathway) :
Contrary to this notion, we have identified the DEAD-box RNA helicase DDX3 as a regulator of the Wnt-ß-catenin network, where it acts as a regulatory subunit of CK1e : In a Wnt dependent manner, DDX3 binds CK1e and directly stimulates its kinase activity, and promotes phosphorylation of the scaffold protein dishevelled