Gene interactions and pathways from curated databases and text-mining

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CHUK — CSF2

Text-mined interactions from Literome

Ebner et al., Blood 2003 : Functional studies demonstrated GMCSF dependent activation of IkappaB kinase activity in endothelial cells, degradation of IkappaB, and activation of NF-kappaB
Catley et al., Br J Pharmacol 2005 (Asthma) : Similarly, IKK beta ( KA ) and I kappa B alpha delta N overexpression also inhibited IL-1beta- and TNF alpha dependent increases in ICAM-1, IL-8 and GM-CSF in addition to IL-1beta mediated increases in cyclooxygenase-2 expression, whereas IKK alpha ( KM ) overexpression had little effect on these outputs
Brummer et al., Med Mycol 2005 (Inflammation) : We postulated that DEX inhibition of NF-kappaB was opposed by induction of IkappaB kinases (IKK) by GM-CSF + conidia stimulation, degradation of IkappaB, and release of nuclear factor kappa B (NF-kappaB)
Catley et al., Mol Pharmacol 2006 (Pulmonary Disease, Chronic Obstructive) : As observed above, ICAM-1, IL-6, IL-8, GM-CSF , RANTES, MCP-1, GROalpha, NAP-2, and ENA-78 expression was reduced by the IKK inhibitors
Grund et al., Mol Pharmacol 2008 (Endometriosis...) : Interestingly, MEK, p38, and IKK inhibitors block TNF-alpha induced IL-8, IL-6, and GM-CSF secretion and 12z invasion, whereas the PI3K inhibitors do not