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CSE — MAPK3
Text-mined interactions from Literome
Volpi et al., Br J Pharmacol 2011
:
Both
CSE- and acrolein evoked VEGF release were
blocked by selective inhibition of p38
MAPK signalling
Pera et al., Am J Physiol Lung Cell Mol Physiol 2012
(MAP Kinase Signaling System) :
Stimulation of these cells with
CS extract (CSE) increased IL-8 release and
ERK-1/2 phosphorylation, as well as I?-Ba degradation and p65 NF-?B subunit phosphorylation ...
CSE induced
ERK-1/2 phosphorylation and I?-Ba degradation were both inhibited by pretreatment with the specific TAK1 inhibitor LL-Z-1640-2 ( 5Z-7-oxozeaenol ; 100 nM ) ... Similarly, expression of dominant negative TAK1 inhibited
CSE induced
ERK-1/2 phosphorylation ... These data indicate that TAK1 plays a major role in
CSE induced
ERK-1/2 and NF-?B signaling and in IL-8 release by human ASM cells
Moretto et al., Am J Physiol Lung Cell Mol Physiol 2012
(MAP Kinase Signaling System...) :
Both
CSE and acrolein
induced p38
mitogen activated protein kinase ( MAPK ) phosphorylation, accompanied by the phosphorylation of MAPK activated kinase 2 (MK2), a known downstream substrate of the p38 MAPK, both in HBSMCs and in human airway epithelial cells