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CSE — MAPK3

Text-mined interactions from Literome

Volpi et al., Br J Pharmacol 2011 : Both CSE- and acrolein evoked VEGF release were blocked by selective inhibition of p38 MAPK signalling
Pera et al., Am J Physiol Lung Cell Mol Physiol 2012 (MAP Kinase Signaling System) : Stimulation of these cells with CS extract (CSE) increased IL-8 release and ERK-1/2 phosphorylation, as well as I?-Ba degradation and p65 NF-?B subunit phosphorylation ... CSE induced ERK-1/2 phosphorylation and I?-Ba degradation were both inhibited by pretreatment with the specific TAK1 inhibitor LL-Z-1640-2 ( 5Z-7-oxozeaenol ; 100 nM ) ... Similarly, expression of dominant negative TAK1 inhibited CSE induced ERK-1/2 phosphorylation ... These data indicate that TAK1 plays a major role in CSE induced ERK-1/2 and NF-?B signaling and in IL-8 release by human ASM cells
Moretto et al., Am J Physiol Lung Cell Mol Physiol 2012 (MAP Kinase Signaling System...) : Both CSE and acrolein induced p38 mitogen activated protein kinase ( MAPK ) phosphorylation, accompanied by the phosphorylation of MAPK activated kinase 2 (MK2), a known downstream substrate of the p38 MAPK, both in HBSMCs and in human airway epithelial cells