Gene interactions and pathways from curated databases and text-mining

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CASP5 — CRK

Text-mined interactions from Literome

Campbell et al., Neuron 2003 : In addition, we report that caspase-3 , an apoptotic protease, is rapidly activated by netrin-1 and LPA in a proteasome- and p38 dependent manner and is required for chemotropic responses
Ehses et al., Endocrinology 2003 : Glucose dependent insulinotropic polypeptide promotes beta- ( INS-1 ) cell survival via cyclic adenosine monophosphate mediated caspase-3 inhibition and regulation of p38 mitogen activated protein kinase
Alvarado-Kristensson et al., J Biol Chem 2005 : Consequently, the early and temporary activation of PP2A in neutrophils impaired not only the p38 MAPK mediated inhibition of caspase 3 but also restored the activity to caspase 3 that had already been phosphorylated and thereby inactivated
Singh et al., Neuroscience 2005 (Nerve Degeneration) : Alternatively, gp120 induced increases in caspase-3 activity, neurite losses and neuronal death were prevented by p38 , but not c-jun-N-terminal kinase, mitogen activated protein kinase inhibition
Holcomb et al., J Biol Chem 2006 : Furthermore, we demonstrate that attachment to an extracellular matrix plays a key role in regulating the apoptotic machinery through caspase mediated cleavage of Abl and Crk-Y221-P
Wang et al., J Mol Cell Cardiol 2006 (Inflammation...) : Following reperfusion, homogenized hearts were analyzed for TNF-alpha, IL-1beta, and IL-6 gene and protein expression, p38 MAPK activation , and the apoptosis related proteins caspase-3 and Bcl-2
Morisco et al., Cardiovasc Res 2007 (Insulin Resistance) : Hypoxia induced cleavage of caspase-3 was mediated by p38 mitogen activated protein kinase ( MAPK )
Zhao et al., Int J Cardiol 2010 (MAP Kinase Signaling System) : Second, we found that activity of p38-MAPK ( mitogen activated protein kinase ) and caspase-3 was elevated in the cells treated with PAF, without altering activity of ERK and JNK, and that PAF induced enhancement of caspase-3 activity was attenuated by application of either BAPTA/AM or SB203580 ( p38 inhibitor )
Rudolf et al., Toxicol Lett 2009 : We show that initially exposure of fibroblasts to Cr ( III ) induced membrane dependent signaling including activation of Rac1 GTPase, Src and apoptosis signal regulating kinase 1 ( ASK-1 ) kinases leading to increased activities of p38 and particularly Jun N-terminal kinase (JNK) and subsequent activation of caspase-3
Hasegawa et al., J Immunol 2009 : ASC mediated AP-1 activation was inhibited by chemical or protein inhibitors for caspase-8, caspase-8 targeting small interfering RNA, and p38 and JNK inhibitors, but not by a caspase-1 inhibitor, caspase-9 or Fas associated death domain protein ( FADD ) dominant negative mutants, FADD- or RICK targeting small interfering RNAs, or a MEK inhibitor, indicating that the ASC induced AP-1 activation is mediated by caspase-8 , p38 , and JNK, but does not require caspase-1, caspase-9, FADD, RICK, or ERK
Wei et al., Nan Fang Yi Ke Da Xue Xue Bao 2009 (Parkinson Disease) : To investigate the effect of p38 mitogen activated protein kinase ( p38MAPK ) on the expression of COX-2 and caspase-3 in the substania nigra ( SN ) of mice with MPTP induced Parkinson disease ( PD )
Wang et al., Arch Pharm Res 2013 : Furthermore, PD98059 ( ERK1/2 inhibitor ) significantly enhanced 2-hydroxy-3-methylanthraquinone induced apoptosis in U937 cells, whereas caspase-3 inhibitor or SB203580 ( p-p38MAPK inhibitor ), decreased apoptosis in U937 cells
Xu et al., Physiol Res 2013 (Disease Models, Animal...) : Saturated hydrogen saline also decreased phosphorylated extracellular signal regulated kinase ( p-ERK ), phosphorylated Jun kinase ( p-JNK ), nuclear factor-kappa B (NF-kappaB), and second mitochondria derived activator of caspase ( Smac ) levels, and increased p38 activation ( P < 0.05 )