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CRH — NOS1
Text-mined interactions from Literome
Weidenfeld et al., Neuroendocrinology 1999
:
These results suggest that : ( 1 ) NO is involved in modulation of the HPA axis responses to neural stimuli which are not dependent on immune factors, ( 2 ) the effect of NO is mediated by inhibition of hypothalamic ME
CRH-41 secretion, and ( 3 ) this effect is probably
mediated by
neuronal NOS and not by inducible NOS
Cantarella et al., Br J Pharmacol 2001
:
Divergent
effects of
corticotropin releasing hormone on endothelial cell
nitric oxide synthase are associated with different expression of CRH type 1 and 2 receptors
Givalois et al., Brain Res Mol Brain Res 2002
:
The acute
effects ( 4 h ) of two
NOS inhibitors ( HP-228 and NMMA ), injected into the left lateral cerebral ventricle of freely moving male rats, on hypothalamic
CRH and pituitary proopiomelacortin (POMC) mRNA levels as well as ACTH plasma levels were evaluated
Karteris et al., J Clin Endocrinol Metab 2005
(Birth Weight...) :
In placental explants,
CRH and UCN
induced mRNA and protein expression of eNOS, but not inducible
NOS , and also caused an acute increase in cGMP levels ( maximal stimulation, 80-90 % above basal ; P < 0.05 )
Ralph et al., Am J Pathol 2007
(Arthritis...) :
CRH enhanced the expression of
nitric-oxide synthase ( NOS III ) to promote NO production from CRH-R1alpha expressing cells
Jain et al., Am J Obstet Gynecol 1997
:
The relaxation induced by corticotropin releasing factor in aortic rings from nonpregnant rats decreased after deendothelization and treatment with N omega-nitro-L-arginine methyl ester ( a
nitric oxide synthase inhibitor ), LY-83,583 ( a guanylate cyclase inhibitor ), or alpha-helical
corticotropin releasing factor 9-41 ( a corticotropin releasing factor antagonist )
Raber et al., Brain research. Brain research reviews 1998
(Disease Models, Animal...) :
The IFNalpha stimulated release of AVP and
CRH appears to be mediated by cyclic GMP production, and this release by IFNalpha and IL-2 may be
mediated in part by activation of constitutive
nitric oxide synthase