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CREB1 — CREBBP

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CREB1 → Complex of CREB1-CREBBP (directlyIncreases, CREB1/CREBBP Activity)
  Evidence: Moreover, PP1 was shown to act as a major CTD phosphatase in nuclear extracts and to affinity-purify with RNA polymerase II. Both PP1 and the nuclear regulator NIPP1 have also been identified as components of the Tat-associated RNA polymerase II complex, which regulates transcription from the human immunodeficiency virus type 1 promoter (40, 275). The transcription factor CREB mediates the expression of cAMP-induced genes by binding to a conserved cAMP-responsive element. Phosphorylation of CREB...
• BioCarta transcription regulation by methyltransferase of carm1: CBP/p300/CREB complex (CREBBP-CREB1-EP300) → BCL-2 (BCL2) (transcription, activates)
• BioCarta inhibition of huntingtons disease neurodegeneration by histone deacetylase inhibitors: histone transacetylase (CREBBP) → CREB (CREB1) (modification, collaborate)
• BioCarta inhibition of huntingtons disease neurodegeneration by histone deacetylase inhibitors: histone transacetylase (CREBBP) → CBP/CREB/CREB complex (CREBBP-CREB1) (modification, collaborate)
  
• BioCarta inhibition of huntingtons disease neurodegeneration by histone deacetylase inhibitors: CREB (CREB1) → CBP/CREB/CREB complex (CREBBP-CREB1) (modification, collaborate)
  
• BioCarta transcription regulation by methyltransferase of carm1: CBP/p300/CREB complex (CREBBP-CREB1-EP300) → p300/CBP complex (CREBBP-EP300) (modification, collaborate)
  
• BioCarta transcription regulation by methyltransferase of carm1: CBP/p300/CREB complex (CREBBP-CREB1-EP300) → CREB (CREB1) (modification, collaborate)
• BioCarta transcription regulation by methyltransferase of carm1: p300/CBP complex (CREBBP-EP300) → CREB (CREB1) (modification, collaborate)
• KEGG Melanogenesis: PRKACA/PRKACB/PRKACG/PRKX → Complex of CREB1-CREB3-CREB3L1-CREB3L2-CREB3L3-CREB3L4-CREBBP-EP300 (protein-protein, activation)
  
• KEGG Melanogenesis: Complex of CREB1-CREB3-CREB3L1-CREB3L2-CREB3L3-CREB3L4-CREBBP-EP300 → MITF (gene expression, expression)
• KEGG Prostate cancer: ATF4/CREB1/CREB3/CREB3L1/CREB3L2/CREB3L3/CREB3L4/CREB5 → CREBBP/EP300 (protein-protein, inhibition)
• NCI Pathway Database HIF-1-alpha transcription factor network: CREB1 (CREB1) → HIF1A/ARNT/Cbp/p300 complex (HIF1A-ARNT-EP300_CREBBP) (transcription, activates)
  Hu et al., Mol Cell Biol 2003, Semenza et al., J Biol Chem 1996, Ebert et al., Mol Cell Biol 1998
  Evidence: mutant phenotype, assay, reporter gene, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: CREB1 — CREBBP Screaton et al., Cell 2004*
• IRef Bind_translation Interaction: CREB1 — CREBBP (two hybrid) Screaton et al., Cell 2004*
• IRef Bind_translation Interaction: CREBBP — CREB1 (coimmunoprecipitation) Martin et al., Nat Immunol 2005*
• IRef Biogrid Interaction: CREBBP — CREB1 (association, x-ray crystallography) Radhakrishnan et al., Cell 1997*
• IRef Biogrid Interaction: CREBBP — CREB1 (direct interaction, pull down) Shimomura et al., J Biol Chem 1996*
• IRef Biogrid Interaction: CREBBP — CREB1 (direct interaction, pull down) Radhakrishnan et al., Cell 1997*
• IRef Biogrid Interaction: CREBBP — CREB1 (direct interaction, pull down) Zhang et al., Mol Cell Biol 2000*
• IRef Biogrid Interaction: CREBBP — CREB1 (physical association, affinity chromatography technology) Sano et al., J Biol Chem 1998*
• IRef Biogrid Interaction: CREBBP — CREB1 (direct interaction, fluorescent resonance energy transfer) Zor et al., J Biol Chem 2002*
• IRef Biogrid Interaction: CREBBP — CREB1 (direct interaction, pull down) Giebler et al., Mol Cell Biol 2000*
• IRef Biogrid Interaction: CREBBP — CREB1 (direct interaction, pull down) Ledo et al., EMBO J 2002*
• IRef Biogrid Interaction: CREBBP — CREB1 (direct interaction, pull down) Ernst et al., Mol Cell Biol 2001*
• IRef Biogrid Interaction: CREBBP — CREB1 (physical association, affinity chromatography technology) Best et al., Proc Natl Acad Sci U S A 2004*
• IRef Biogrid Interaction: CREBBP — CREB1 (direct interaction, pull down) Best et al., Proc Natl Acad Sci U S A 2004*
• IRef Biogrid Interaction: CREBBP — CREB1 (physical association, affinity chromatography technology) Chan et al., J Mol Cell Cardiol 2010*
• IRef Biogrid Interaction: CREBBP — CREB1 (association, x-ray crystallography) Yang et al., Nature 2006
• IRef Biogrid Interaction: CREBBP — CREB1 (physical association, affinity chromatography technology) Solomou et al., J Immunol 2001*
• IRef Biogrid Interaction: CREBBP — CREB1 (physical association, affinity chromatography technology) Poon et al., Endocrinology 2008*
• IRef Biogrid Interaction: CREBBP — CREB1 (direct interaction, two hybrid) Du et al., J Biol Chem 1998*
• IRef Biogrid Interaction: CREBBP — CREB1 (direct interaction, two hybrid) Kim et al., J Mol Endocrinol 2005*
• IRef Biogrid Interaction: CREBBP — CREB1 (physical association, affinity chromatography technology) Shi et al., Proc Natl Acad Sci U S A 2004*
• IRef Biogrid Interaction: CREBBP — CREB1 (direct interaction, pull down) Sano et al., J Biol Chem 1998*
• IRef Hprd Interaction: CREB1 — CREBBP (in vivo) Shi et al., Proc Natl Acad Sci U S A 2004*, Radhakrishnan et al., Cell 1997*
• IRef Hprd Interaction: CREB1 — CREBBP (in vitro) Shi et al., Proc Natl Acad Sci U S A 2004*, Radhakrishnan et al., Cell 1997*
• IRef Intact Interaction: CREB1 — CREBBP (physical association, pull down) Ravnskjaer et al., EMBO J 2007*
• IRef Intact Interaction: CREB1 — CREBBP (physical association, anti tag coimmunoprecipitation) Wang et al., Cancer Cell 2010*
• IRef Intact Interaction: Complex of CREB1-CREBBP-MEIS1 (association, anti tag coimmunoprecipitation) Wang et al., Cancer Cell 2010*
• IRef Ophid Interaction: CREB1 — CREBBP (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Dal Peraro et al., Eur Biophys J 2001 : Cyclic AMP response element binding protein ( CREB ) is involved in activation of transcriptional DNA machinery by binding to the coactivator CREB binding protein (CBP)
Konesky et al., J Virol 2006 : Binding of Tax and CREB to the vCREs promotes association of p300/CBP into the complex and leads to transcriptional activation
Yun et al., Mol Endocrinol 2012 : OT also increased cAMP response element binding ( CREB)/CREB binding protein ( CBP ) expression in the nucleus and induced the formation of CREB1/NF-?B/CBP complexes, which was blocked by the NF-?B-specific small interfering RNA, NF-?B inhibitors, SN50, and bay11-7082
Suire et al., Eur J Biochem 1996 : Since we observed important dissociation kinetics, we hypothesized that the binding of CREB to the PRII site is stabilized by CREB binding protein (CBP) or by chicken-ovalbumin-upstream-promoter transcription factor ( COUP-TF ) binding to PRI site near to PRII