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CREB5 — SIRT1

Text-mined interactions from Literome

Gao et al., Nature 2010 (Memory Disorders) : SIRT1 normally functions to limit expression of miR-134 via a repressor complex containing the transcription factor YY1, and unchecked miR-134 expression following SIRT1 deficiency results in the downregulated expression of CREB and brain derived neurotrophic factor (BDNF), thereby impairing synaptic plasticity
Noriega et al., EMBO Rep 2011 : CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability
Fusco et al., Proc Natl Acad Sci U S A 2012 : Moreover, CREB deficiency drastically reduces the expression of Sirt-1 and the induction of genes relevant to neuronal metabolism and survival in the cortex and hippocampus of dietary restricted animals ... Biochemical studies reveal a complex interplay between CREB and Sirt-1 : CREB directly regulates the transcription of the sirtuin in neuronal cells by binding to Sirt-1 chromatin ; Sirt-1, in turn, is recruited by CREB to DNA and promotes CREB dependent expression of target gene peroxisome proliferator activated receptor-? coactivator-1a and neuronal NO Synthase
Monteserin-Garcia et al., FASEB J 2013 : Therefore, the present study investigates how Sirt1 affects CREB function and GH synthesis ... Sirt1 activation and overexpression suppressed forskolin induced CREB-Ser ( 133 ) phosphorylation, but no effect was seen with vehicle and empty plasmid controls