Gene interactions and pathways from curated databases and text-mining

◀ Back to PPP2CA

CREB3 — PPP2CA

Text-mined interactions from Literome

Roach et al., Infect Immun 2005 : Our studies are the first to demonstrate an important role for the transcription factor CREB in TNF-alpha production by mycobacterium infected macrophages, as well as a role for M. avium 's induction of PP2A phosphatase activity as a mechanism to limit macrophage activation
Mauna et al., Hippocampus 2011 : Thus, both PP1 and PP2A regulate CREB during LTD in area CA1, although possibly through different signaling pathways
Ferron et al., Cardiovasc Res 2011 (Calcium Signaling...) : Aldosterone activated cAMP-response element binding protein ( CREB ), and this activation was enhanced by blocking I ( CaT ) or by inhibiting protein phosphatase 2A (PP2A) activity
Chung et al., J Biol Chem 2011 : One pathway involves PKC-a catalyzed phosphorylation of CREB and the other involves a PKC mediated the PP2A catalyzed dephosphorylation of Akt at Ser ( 473 ) which in turn leads to FOXO3a Ser ( 253 ) dephosphorylation and its activation
Cho et al., PloS one 2012 (Diabetes Mellitus, Type 2...) : Importantly, overexpression of PP2A reversed the adverse effects of chronic hyperglycemia and successfully restored the transient activation of CREB and ICER ... Conversely, depletion of PP2A with siRNA was sufficient to disrupt the negative feedback regulation of CREB and induce hyperglycemic phenotypes even under low glucose conditions
Christen et al., Environ Sci Technol 2013 : Phosphorylated P-CREB , a transcription factor for PP2A, leads to elevated expression of PP2A