Gene interactions and pathways from curated databases and text-mining

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CREB3 — NPY

Text-mined interactions from Literome

Sheriff et al., Peptides 2002 : Although activation of the Y ( 1 ) receptor leads to an increase in CREB phosphorylation, [ Leu ( 31 ), Pro ( 34 ) ] -NPY inhibited CREB phosphorylation in KN-93 treated cells
Wand et al., J Clin Invest 2005 (Alcohol-Induced Disorders, Nervous System...) : They report that decreased phosphorylation of cAMP responsive element binding protein ( CREB ) resulted in decreased neuropeptide Y (NPY) expression in the central amygdala of alcohol preferring rats, causing high anxiety-like behavior
Hsieh et al., Am J Physiol Endocrinol Metab 2007 (Anorexia) : To determine whether PKA or CREB was involved in the anorectic response, intracerebroventricular infusions of antisense oligonucleotide ( or missense control ) were performed 60 min before daily AMPH treatment in conscious rats, and results showed that either PKA or CREB knockdown could block AMPH induced anorexia as well as restore NPY mRNA level, indicating the respective involvement of PKA and CREB signaling in the regulation of NPY gene expression
Son et al., J Cell Mol Med 2011 : Notably, only Y1 receptor, but not Y5 receptor, is responsible for the NPY induced activation of cAMP-response element binding ( CREB ) in hESCs