Gene interactions and pathways from curated databases and text-mining

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AKT1 — CREB3

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Grimes et al., J Neurochem 2001 : Activation of Akt ( protein kinase B ) with serum increased phospho-serine-9-GSK3 beta ( the inactive form of the enzyme ), inhibited GSK3 beta activity, and increased CREB DNA binding activity
Trümper et al., J Endocrinol 2002 (MAP Kinase Signaling System) : These interactions included : ( i ) a central role of tyrosine phosphorylation for stimulation of PKA/CREB, MAPK and PI3-kinase/PKB, ( ii ) inhibition of PKA/CREB by the MAPK pathway at the level of MAPK kinase-1 or downstream, ( iii ) activation of MAPK signaling by PI3-kinase and PKA at the level of extracellular-signal regulated kinase 1/2 or upstream, and ( iv ) activation of PKB by MAPK and PKA signaling at the level of PKB or upstream
Milani et al., J Neurochem 2003 (Neuroblastoma) : Moreover, TRAIL increased CREB phosphorylation and phospho-CREB DNA binding activity in a phosphatidylinositol 3-kinase (PI 3K)/Akt dependent manner
Misra et al., J Cell Biochem 2004 : Silencing of the CREB gene with dsRNA homologous in sequence to the target gene, markedly reduced the levels of CREB mRNA activation of CREB, PI 3-kinase, Akt , and p70s6k in alpha2M* stimulated macrophages
Yano et al., J Pharmacol Sci 2005 (Brain Ischemia) : On the other hand, during induction of ischemic tolerance, Akt activity gradually and persistently increased in the CA1 neurons with transient increase in CREB phosphorylation
Willaime-Morawek et al., Brain Res Mol Brain Res 2005 : In non-neuronal cells, Akt phosphorylates and activates the transcription factor CREB , implicated in the transcription of the anti-apoptotic bcl-2 gene
Jia et al., J Nutr 2006 : Inhibition of AKT suppressed both CREB/ATF1 phosphorylation and IL-6 transcription ... These data suggest that DHA consumption suppresses DON induced IL-6 transcription in macrophages in part by interfering with AKT dependent phosphorylation and subsequent binding of CREB/ATF1 to the IL-6 promoter
Misra et al., J Cell Biochem 2007 : Recently, we reported that silencing CREB gene expression by RNAi significantly attenuates forskolin induced activation of Akt1
Wang et al., J Biomed Sci 2007 : In conclusion, A20 attenuates neointimal formation after arterial injury as well as cell proliferation and migration in response to TNF-alpha in VSMCs through blocking PI3K/Akt/GSKbeta dependent activation of CREB
Kato et al., Biochem Biophys Res Commun 2007 : Differential activation of CREB by Akt1 and Akt2
Caravatta et al., J Cell Physiol 2008 (Leukemia...) : PI3-K/Akt dependent activation of cAMP-response element binding ( CREB ) protein in Jurkat T leukemia cells treated with TRAIL
Song et al., Gut 2007 (Adenocarcinoma...) : Unconjugated bile acids induce CREB and AP-1 dependent COX-2 expression in Barrett 's oesophagus and OA through ROS mediated activation of PI3K/AKT and ERK1/2
Liang et al., Mol Cell Neurosci 2008 : Lithium inhibits Smad3/4 transactivation via increased CREB activity induced by enhanced PKA and AKT signaling
Su et al., Cancer Immunol Immunother 2008 : Combined PGE2 and adenosine treatment resulted in augmentation of cAMP production, PKA activity, CREB phosphorylation and inhibition of Akt phosphorylation
Yao et al., J Neurosci 2009 : Blocking TRPC channels and specific downregulation of TRPC channels 1 and 5 resulted in suppression of CCL2 induced ERK/CREB activation but not Akt/NF-kappaB activation
Yang et al., PloS one 2010 (Brain Ischemia...) : Further studies showed that EDC increased p-CREB and BDNF in the CA1 region in an ERK- and Akt dependent manner, and that cognitive outcome after GCI was preserved by EDC in an ER-dependent manner
Kim et al., J Lipid Res 2010 : The lipogenic effects of GIP in the presence of insulin are therefore at least partially mediated by upregulation of adipocyte LPL gene transcription through a pathway involving PI3-K/PKB/AMPK dependent CREB/TORC2 activation
Kim et al., J Invest Dermatol 2011 (Carcinoma, Squamous Cell...) : Expression of constitutively active Akt blocked RES inhibition of CREB and TGF-ß2, and rescued RES inhibition of cellular invasiveness
Shanmugam et al., J Mol Cell Cardiol 2011 (Cardiomyopathy, Hypertrophic) : Ang-II induced WISP1 expression via superoxide/Akt/GSK3ß/ß-catenin/TCF/LEF and by Akt dependent CREB activation
Yano et al., Cell communication and signaling : CCS 2012 : PI3K/Akt dependent activation of cAMP responsive element binding protein ( CREB)-1 induced expression of matrix metalloproteinase (MMP)-9 and suppressing MMP activity by doxycycline partially reversed FN accumulation in the InsR silenced cells
Du et al., J Biol Chem 1998 : CREB is a regulatory target for the protein kinase Akt/PKB ... CREB is a regulatory target for the protein kinase Akt/PKB ... Recent studies showing that CREB and its paralog CREM are required for survival of certain cell types prompted us to examine whether CREB is a nuclear target for activation via the growth factor dependent Ser/Thr kinase Akt/PKB ... When overexpressed in serum stimulated cells, Akt/PKB potently induced Ser-133 phosphorylation of CREB and promoted recruitment of CBP ... When overexpressed in serum stimulated cells, Akt/PKB potently induced Ser-133 phosphorylation of CREB and promoted recruitment of CBP ... Akt/PKB induced CREB activity only in response to serum stimulation, and this effect was suppressed by the phosphatidylinositol 3-kinase inhibitor LY 294002 ... Akt/PKB induced CREB activity only in response to serum stimulation, and this effect was suppressed by the phosphatidylinositol 3-kinase inhibitor LY 294002