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CPOX — IL5
Text-mined interactions from Literome
Moore et al., J Appl Physiol 2001
:
In human cultured airway smooth muscle cells,
interleukin (IL)-1 beta
increases cyclooxygenase (COX)-2 expression and PGE ( 2 ) release, ultimately resulting in decreased beta-adrenergic responsiveness
Hashimoto et al., J Immunol 2005
(Hypersensitivity...) :
Allergen sensitization and airway challenge alone led to undetectable levels of IL-5 and IL-13 in the lungs of IL-4, IL-4Ralpha, and STAT6 knockout ( KO ) mice, but
COX inhibition during the development of allergic inflammation
resulted in wild-type levels of
IL-5 and IL-13 and heightened airway eosinophilia in each of the three KO mice
Helmersson et al., Free radical research 2005
(Cardiovascular Diseases...) :
This study investigated the longitudinal association between serum selenium ( s-Se ) and a golden standard indicator of oxidative stress in vivo ( 8-iso-prostaglandin F2alpha, a major F2-isoprostane ), an indicator of
cyclooxygenase (COX) mediated inflammation ( prostaglandin F2alpha ), high sensitive C-reactive protein ( hsCRP ),
interleukin-6 (IL-6) and serum amyloid A protein (SAA) in a follow-up study of 27 years
Zhou et al., J Immunol 2008
(Inflammation...) :
COX inhibition during sensitization increased the numbers of mature dendritic cells and activated CD4 T cells in the spleen and
augmented OVA-specific
IL-5 and IL-13 responses of the splenic CD4 T cells at day 5 after sensitization
Dean et al., J Biol Chem 1999
:
We have previously shown that the pyridinyl imidazole SB 203580, which inhibits it, blocks the
interleukin-1 induction of
cyclooxygenase-2 (COX-2) and matrix metalloproteinase 1 and 3 mRNAs in fibroblasts