Gene interactions and pathways from curated databases and text-mining

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AKT1 — CPOX

Text-mined interactions from Literome

Lee et al., J Biol Chem 2003 : LY294002, dominant negative ( DN ) phosphatidylinositol 3-kinase (PI3K), or AKT ( DN ) inhibited NFkappaB activation, p65 transactivation, and cyclooxygenase-2 (COX-2) expression induced by lauric acid or constitutively active ( CA ) TLR4
Chang et al., Mol Pharmacol 2004 : The YC-1 induced increase in COX activity was also blocked by manumycin A, wortmannin, PDTC, and the dominant negative mutants for Ras ( RasN17 ), Akt ( Akt DN ), and IkappaBalpha ( IkappaBalphaM )
Ning et al., Radiat Res 2007 : Both radiation and cRGD induced Akt phosphorylation, up-regulated COX2 expression, and increased PGE2 production in HUVECs
Hill et al., Mol Cancer Ther 2012 (Carcinoma, Pancreatic Ductal...) : Mechanistically, COX-2 overexpression increases p-AKT levels in the precursor lesions of Pdx1 ( + ) ; K-ras ( G12D ) ( /+ ) ; Pten ( lox ) ( /+ ) mice in the absence of Pten LOH
GutiƩrrez-Venegas et al., Mol Biol Rep 2013 (Chronic Periodontitis) : We studied the role of the flavonoids fisetin, luteolin, myricetin, and morin in inhibiting the activation of mitogen activated protein kinase ( MAPK ) and AKT as well as their role in lipopolysaccharide (LPS) induced cyclooxygenase-2 (COX-2) transcription