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AKT1 — CNTF

Text-mined interactions from Literome

Ott et al., J Endocrinol 2002 : CNTF stimulates STAT3, MAP kinase, Akt , and p70 S6 kinase
Zvonic et al., J Biol Chem 2003 : In order to investigate the effects of CNTF on fat cells, we examined the expression of CNTF receptor complex proteins ( LIFR, gp130, and CNTFRalpha ) during adipocyte differentiation and the effects of CNTF on STAT, Akt , and MAPK activation
de Melo Reis et al., Brain Res 2008 : Murine Müller glial conditioned medium ( MMG ) was concentrated and at 1 : 1 dilution supported 100 % survival of chick or rat sympathetic neurons after 48 h compared to < 5 % in controls. Partial purification of the MMG using centriprep concentrators showed that trophic activity is from molecules above 10 kDa. MMG stimulated AKT , ERK and pStat3 in sympathetic neurons. Sympathetic or DRG neuronal survival induced by MMG was blocked by anti-human NGF, but not by anti-human CNTF ( sympathetic ) or by anti-BDNF ( DRGs ) neutralizing antibodies. MMG also induced neurite outgrowth in P4 mice retinal explants and on isolated RGC. RGCs plated on top of Müller glia cells had a much better survival rate ( > 80 %, 96 h ) compared to laminin+poly-L-lysine substrates
Sango et al., Histochem Cell Biol 2008 : Western blot analysis revealed that CNTF induced phosphorylation of STAT3, Akt , and ERK1/2 in the neurons
Steinberg et al., Diabetes 2009 (Obesity) : CNTF also increases Akt signaling in neurons and adipocytes ... The effects of CNTF on skeletal muscle glucose uptake and AMPK/Akt signaling were investigated in incubated soleus and extensor digitorum longus (EDL) muscles from muscle-specific AMPKalpha2 kinase-dead, gp130 ( DeltaSTAT ), and lean and obese ob/ob and high-fat fed mice ... CNTF stimulated glucose uptake and Akt phosphorylation were substantially reduced in obesity ( high-fat diet and ob/ob ) despite normal induction of gp130/AMPK signaling -- effects also observed when treating myotubes with C2-ceramide