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CITED2 — HIF1A

Pathways - manually collected, often from reviews:

• NCI Pathway Database HIF-1-alpha transcription factor network: Cbp/p300/CITED2 complex (EP300_CREBBP-CITED2) → HIF1A/ARNT complex (HIF1A-ARNT) (modification, collaborate)
  Lando et al., Science 2002, Hewitson et al., J Biol Chem 2002, Kato et al., J Biol Chem 2004, Arany et al., Proc Natl Acad Sci U S A 1996, Kallio et al., EMBO J 1998, Bhattacharya et al., Genes Dev 1999
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database HIF-1-alpha transcription factor network: Cbp/p300/CITED2 complex (EP300_CREBBP-CITED2) → HIF1A/ARNT/Cbp/p300/HDAC7 complex (HIF1A-ARNT-EP300_CREBBP-HDAC7) (modification, collaborate)
  Lando et al., Science 2002, Hewitson et al., J Biol Chem 2002, Kato et al., J Biol Chem 2004, Arany et al., Proc Natl Acad Sci U S A 1996, Kallio et al., EMBO J 1998, Bhattacharya et al., Genes Dev 1999
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database HIF-1-alpha transcription factor network: Cbp/p300/CITED2 complex (EP300_CREBBP-CITED2) → HIF1A (HIF1A) (modification, collaborate) Lando et al., Science 2002, Hewitson et al., J Biol Chem 2002, Kato et al., J Biol Chem 2004, Arany et al., Proc Natl Acad Sci U S A 1996, Kallio et al., EMBO J 1998, Bhattacharya et al., Genes Dev 1999
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database HIF-1-alpha transcription factor network: Cbp/p300/CITED2 complex (EP300_CREBBP-CITED2) → HIF1A/ARNT/Cbp/p300 complex (HIF1A-ARNT-EP300_CREBBP) (modification, collaborate)
  Lando et al., Science 2002, Hewitson et al., J Biol Chem 2002, Kato et al., J Biol Chem 2004, Arany et al., Proc Natl Acad Sci U S A 1996, Kallio et al., EMBO J 1998, Bhattacharya et al., Genes Dev 1999
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database HIF-1-alpha transcription factor network: HIF1A/ARNT complex (HIF1A-ARNT) → CITED2 (CITED2) (modification, collaborate) Lando et al., Science 2002, Hewitson et al., J Biol Chem 2002, Kato et al., J Biol Chem 2004, Arany et al., Proc Natl Acad Sci U S A 1996, Kallio et al., EMBO J 1998, Bhattacharya et al., Genes Dev 1999
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database HIF-1-alpha transcription factor network: HIF1A/ARNT/Cbp/p300/HDAC7 complex (HIF1A-ARNT-EP300_CREBBP-HDAC7) → CITED2 (CITED2) (modification, collaborate) Lando et al., Science 2002, Hewitson et al., J Biol Chem 2002, Kato et al., J Biol Chem 2004, Arany et al., Proc Natl Acad Sci U S A 1996, Kallio et al., EMBO J 1998, Bhattacharya et al., Genes Dev 1999
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database HIF-1-alpha transcription factor network: HIF1A (HIF1A) → CITED2 (CITED2) (modification, collaborate) Lando et al., Science 2002, Hewitson et al., J Biol Chem 2002, Kato et al., J Biol Chem 2004, Arany et al., Proc Natl Acad Sci U S A 1996, Kallio et al., EMBO J 1998, Bhattacharya et al., Genes Dev 1999
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database HIF-1-alpha transcription factor network: CITED2 (CITED2) → HIF1A/ARNT/Cbp/p300 complex (HIF1A-ARNT-EP300_CREBBP) (modification, collaborate)
  Lando et al., Science 2002, Hewitson et al., J Biol Chem 2002, Kato et al., J Biol Chem 2004, Arany et al., Proc Natl Acad Sci U S A 1996, Kallio et al., EMBO J 1998, Bhattacharya et al., Genes Dev 1999
  Evidence: mutant phenotype, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• MIPS CORUM VEGF transcriptional complex: VEGF transcriptional complex complex (APEX1-HIF1A-STAT3-CITED1-CITED2-CITED4) Gray et al., Oncogene 2005
• IRef Corum Interaction: Complex of CITED4-HIF1A-CITED1-STAT3-CITED2-APEX1 (association, coimmunoprecipitation) Gray et al., Oncogene 2005
• IRef Hprd Interaction: CITED2 — HIF1A (in vitro) Freedman et al., Nat Struct Biol 2003*

Text-mined interactions from Literome

Yin et al., Proc Natl Acad Sci U S A 2002 (Heart Defects, Congenital...) : The mRNA levels of several HIF-1alpha-responsive genes, such as vascular endothelial growth factor ( VEGF ), Glut1, and phosphoglycerate kinase 1, increased in the Cited2 ( -/- ) hearts
van den Beucken et al., Radiother Oncol 2007 : We show using HIF-1alpha null MEF cells that transcriptional induction of Cited2 during hypoxia is dependent on HIF-1alpha
Shin et al., Oncogene 2008 (Carcinoma, Hepatocellular...) : Both the activity and the p300 binding of HIF-1alpha were inhibited by CITED2 expression and recovered by CITED2 siRNA in the presence of MG132
Bhattacharya et al., Genes Dev 1999 (Anoxia) : Virtually all endogenous p35srj is bound to p300/CBP in vivo, and it inhibits HIF-1 transactivation by blocking the HIF-1alpha/p300 CH1 interaction