Gene interactions and pathways from curated databases and text-mining

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CISH — STAT3

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Novak et al., Growth Factors 1999 : The expression of the SOCS proteins had no effect on CSF-1 mediated STAT3 tyrosine phosphorylation ; however, SOCS-1 and SOCS-3 reduced the tyrosine phosphorylation of STAT3 in response to IL-6 but did not abolish it
Banks et al., J Biol Chem 2000 : In contrast, SOCS3 mRNA accumulation requires Tyr ( 1138 ) -mediated STAT3 activation
Shen et al., FEBS Lett 2000 : Injection of IL-10 into mice activated STAT3 but not STAT1 tyrosine phosphorylation and induced suppressor of cytokine signal 2 (SOCS2), SOCS3, and cytokine-inducible SH2 protein (CIS) mRNA expression in the liver
Suzuki et al., J Exp Med 2001 (Colitis...) : CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation
Hamanaka et al., Circ Res 2001 (Hypotension) : Forced expression of JAB or CIS3 , but not other CISs, directly blocked CT-1 induced STAT3 activation in 293 cells
Ding et al., J Immunol 2003 : Induction of SOCS molecules is dependent on STAT3 activation by IL-10R1
Qing et al., Crit Care Med 2003 (Disease Models, Animal...) : This anti-inflammatory reaction observed in the hypothermic group was associated with a higher expression of suppressor of cytokine signaling-3 and with increased activation of STAT-3
Brender et al., Leukemia 2005 (Lymphoma, T-Cell) : The constitutive activation of Stat3 leads to a constitutive expression of suppressor of cytokine signalling (SOCS)-3
Tokumaru et al., Biochem Biophys Res Commun 2005 : In conclusion, SOCS3/CIS3 regulates HGF induced keratinocyte migration by inhibiting STAT3 phosphorylation
Lee et al., Mol Cancer Ther 2006 (Carcinoma, Squamous Cell...) : Suppressor of cytokine signaling-1 ( SOCS-1 ) has been implicated recently in the negative regulation of IL-6R/Janus activated kinase ( JAK ) -mediated activation of STAT3 , suggesting that SOCS-1 could affect alternative activation of STAT3 by EGFR, IL-6R, and associated kinases
Ozawa et al., Dev Biol 2007 : Interestingly, SOCS3 protein expression was first detected postnatally, after STAT3 activation was mostly downregulated
Rigby et al., Oncogene 2007 (Colonic Neoplasms...) : In vitro, SOCS3 overexpression reduced proliferation, IL-6 mediated STAT3 activation and tumor necrosis factor (TNF) alpha mediated NF-kappaB activation
Ehlting et al., J Immunol 2007 (MAP Kinase Signaling System) : The potential of some proinflammatory mediators to inhibit gp130 dependent STAT3 activation by enhancing suppressor of cytokine signaling (SOCS) 3 expression represents an important molecular mechanism admitting the modulation of the cellular response toward gp130 mediated signals
Kurdi et al., J Cardiovasc Pharmacol 2007 (Heart Diseases) : We propose that the protective character of IL-6-type cytokine signaling in cardiac myocytes is determined principally by three mechanisms : redox status of the nonreceptor tyrosine kinase Janus kinase 1 (JAK) 1 that activates STAT3, phosphorylation of STAT3 within the transcriptional activation domain on serine 727, and STAT3 mediated induction of suppressor of cytokine signaling (SOCS) 3 that terminates IL-6-type cytokine signaling
Bullock et al., Structure 2007 : In accordance, SOCS4 reduces STAT3 signaling from EGFR through increased receptor degradation
Seki et al., J Hepatol 2008 : Here, we investigated this hypothesis by introducing suppressor of cytokine signaling (SOCS)-1 and SOCS3, potent negative regulators of STAT3 signaling, selectively in hepatocytes
Zhu et al., J Invest Dermatol 2008 : We addressed this question genetically by deleting the suppressor of cytokine signaling (SOCS)3 , a negative regulator of gp130 mediated STAT3 activation
Xu et al., J Mol Biol 2008 (Teratocarcinoma) : Transcriptional activation of the suppressor of cytokine signaling-3 ( SOCS-3 ) gene via STAT3 is increased in F9 REX1 ( ZFP-42 ) knockout teratocarcinoma stem cells relative to wild-type cells
Choy et al., Genome medicine 2010 : We further determined that STAT3 was necessary for the p53-RELA complex to associate with this cis-element and for mir-21 expression
Guo et al., PloS one 2012 : A novel viral SOCS from infectious spleen and kidney necrosis virus : interacts with Jak1 and inhibits IFN-a induced Stat1/3 activation
Li et al., Immunity 2012 (Autoimmune Diseases...) : We discovered that Egr2 and/or Egr3 directly induced expression of suppressor of cytokine signaling-1 ( SOCS1 ) and SOCS3, inhibitors of STAT1 and STAT3 , and also blocked the function of Batf, an AP-1 inhibitor, in B and T cells
Yang et al., Nat Immunol 2013 (Asthma...) : Here we found that the SOCS protein CIS , which was substantially induced by interleukin 4 (IL-4), negatively regulated the activation of STAT3 , STAT5 and STAT6 in T cells
Masuhara et al., Biochem Biophys Res Commun 1997 : Transient expression of JAB and CIS3 , but not other CISs, strongly inhibited leukemia inhibitory factor (LIF) induced STAT3-reporter gene activation in 293 cells