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CISH — STAT3
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Novak et al., Growth Factors 1999
:
The expression of the
SOCS proteins
had no effect on CSF-1 mediated
STAT3 tyrosine phosphorylation ; however, SOCS-1 and SOCS-3 reduced the tyrosine phosphorylation of STAT3 in response to IL-6 but did not abolish it
Banks et al., J Biol Chem 2000
:
In contrast,
SOCS3 mRNA accumulation
requires Tyr ( 1138 ) -mediated
STAT3 activation
Shen et al., FEBS Lett 2000
:
Injection of IL-10 into mice activated
STAT3 but not STAT1 tyrosine phosphorylation and
induced suppressor of cytokine signal 2 (SOCS2), SOCS3, and
cytokine-inducible SH2 protein (CIS) mRNA expression in the liver
Suzuki et al., J Exp Med 2001
(Colitis...) :
CIS3/SOCS3/SSI3 plays a negative regulatory role in
STAT3 activation and intestinal inflammation
Hamanaka et al., Circ Res 2001
(Hypotension) :
Forced expression of JAB or
CIS3 , but not other CISs, directly
blocked CT-1 induced
STAT3 activation in 293 cells
Ding et al., J Immunol 2003
:
Induction of
SOCS molecules is
dependent on
STAT3 activation by IL-10R1
Qing et al., Crit Care Med 2003
(Disease Models, Animal...) :
This anti-inflammatory reaction observed in the hypothermic group was associated with a higher expression of
suppressor of cytokine signaling-3 and with increased
activation of
STAT-3
Brender et al., Leukemia 2005
(Lymphoma, T-Cell) :
The constitutive activation of
Stat3 leads to a constitutive expression of
suppressor of cytokine signalling (SOCS)-3
Tokumaru et al., Biochem Biophys Res Commun 2005
:
In conclusion,
SOCS3/CIS3 regulates HGF induced keratinocyte migration by inhibiting
STAT3 phosphorylation
Lee et al., Mol Cancer Ther 2006
(Carcinoma, Squamous Cell...) :
Suppressor of cytokine signaling-1 ( SOCS-1 ) has been implicated recently in the negative
regulation of IL-6R/Janus activated kinase ( JAK ) -mediated activation of
STAT3 , suggesting that SOCS-1 could affect alternative activation of STAT3 by EGFR, IL-6R, and associated kinases
Ozawa et al., Dev Biol 2007
:
Interestingly,
SOCS3 protein expression was first
detected postnatally, after
STAT3 activation was mostly downregulated
Rigby et al., Oncogene 2007
(Colonic Neoplasms...) :
In vitro,
SOCS3 overexpression
reduced proliferation, IL-6 mediated
STAT3 activation and tumor necrosis factor (TNF) alpha mediated NF-kappaB activation
Ehlting et al., J Immunol 2007
(MAP Kinase Signaling System) :
The potential of some proinflammatory mediators to
inhibit gp130 dependent
STAT3 activation by enhancing
suppressor of cytokine signaling (SOCS) 3 expression represents an important molecular mechanism admitting the modulation of the cellular response toward gp130 mediated signals
Kurdi et al., J Cardiovasc Pharmacol 2007
(Heart Diseases) :
We propose that the protective character of IL-6-type cytokine signaling in cardiac myocytes is determined principally by three mechanisms : redox status of the nonreceptor tyrosine kinase Janus kinase 1 (JAK) 1 that activates STAT3, phosphorylation of STAT3 within the transcriptional activation domain on serine 727, and
STAT3 mediated
induction of
suppressor of cytokine signaling (SOCS) 3 that terminates IL-6-type cytokine signaling
Bullock et al., Structure 2007
:
In accordance,
SOCS4 reduces
STAT3 signaling from EGFR through increased receptor degradation
Seki et al., J Hepatol 2008
:
Here, we investigated this hypothesis by introducing
suppressor of cytokine signaling (SOCS)-1 and SOCS3, potent negative
regulators of
STAT3 signaling, selectively in hepatocytes
Zhu et al., J Invest Dermatol 2008
:
We addressed this question genetically by deleting the
suppressor of cytokine signaling (SOCS)3 , a negative
regulator of gp130 mediated
STAT3 activation
Xu et al., J Mol Biol 2008
(Teratocarcinoma) :
Transcriptional
activation of the
suppressor of cytokine signaling-3 ( SOCS-3 ) gene via
STAT3 is increased in F9 REX1 ( ZFP-42 ) knockout teratocarcinoma stem cells relative to wild-type cells
Choy et al., Genome medicine 2010
:
We further determined that
STAT3 was
necessary for the p53-RELA complex to associate with this
cis-element and for mir-21 expression
Guo et al., PloS one 2012
:
A novel viral
SOCS from infectious spleen and kidney necrosis virus : interacts with Jak1 and
inhibits IFN-a induced
Stat1/3 activation
Li et al., Immunity 2012
(Autoimmune Diseases...) :
We discovered that Egr2 and/or Egr3 directly induced expression of
suppressor of cytokine signaling-1 ( SOCS1 ) and SOCS3,
inhibitors of STAT1 and
STAT3 , and also blocked the function of Batf, an AP-1 inhibitor, in B and T cells
Yang et al., Nat Immunol 2013
(Asthma...) :
Here we found that the SOCS protein
CIS , which was substantially induced by interleukin 4 (IL-4), negatively
regulated the activation of
STAT3 , STAT5 and STAT6 in T cells
Masuhara et al., Biochem Biophys Res Commun 1997
:
Transient expression of JAB and
CIS3 , but not other CISs, strongly
inhibited leukemia inhibitory factor (LIF) induced
STAT3-reporter gene activation in 293 cells