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CHKA — MAPK3

Text-mined interactions from Literome

Zagozdzon et al., Cell Signal 2006 (MAP Kinase Signaling System) : In this work, we compared the effect of CHK versus Csk on MAPK signaling and elucidated the signaling pathway mediated by CHK leading to the activation of Erk1/2 ... Exogenous expression of wild-type CHK , but not Csk or a dead-kinase mutant of CHK, resulted in enhanced Erk1/2 phosphorylation in PC12 cells
Yalcin et al., Oncogene 2010 (Neoplasms, Experimental) : Selective inhibition of choline kinase simultaneously attenuates MAPK and PI3K/AKT signaling
Poehlmann et al., Pathol Res Pract 2010 (Neoplasms) : Importantly, as current evidence also suggests a role of MAPK 's ( mitogen activated protein kinases ) in cell cycle checkpoint control, we describe in this review both the ATR/ATM-Chk1/Chk2 signaling pathways as well as the regulation of cell cycle checkpoints by MAPK 's as molecular mechanisms in DDR, and how their dysfunction is related to cancer development
Dai et al., Blood 2011 (MAP Kinase Signaling System...) : The dual Src/Abl inhibitors BMS354825 and SKI-606 blocked Chk1-inhibitor induced extracellular signal regulated kinase 1/2 ( ERK1/2 ) activation, markedly increasing apoptosis in association with BimEL up-regulation, p34 ( cdc2 ) activation, and DNA damage in MM cell lines and primary CD138 ( + ) MM samples