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CHGA — IGF1
Text-mined interactions from Literome
Lee et al., Endocrinology 1999
:
IGF-I and TGF-alpha did not
increase intestinal
chromogranin A (CGA) gene expression, a marker of endocrine cells, or the density of PYY containing cells in the colon, indicating that the elevations in intestinal gut peptide gene expression by IGF-I and TGF-alpha are not due simply to an increased number of enteroendocrine cells
Mergler et al., Neuroendocrinology 2005
(Neuroendocrine Tumors...) :
It is not known, whether VOCCs play a role in the
IGF-1 dependent regulation of
CgA secretion in NET cells ... We therefore studied the effects of IGF-1 on individual VOCC subtypes and characterized their role in mediating
IGF-1 dependent regulation of
CgA secretion in NET cells ...
IGF-1 potently
induced CgA secretion
Mergler et al., Neuroendocrinology 2007
(Neuroendocrine Tumors...) :
Our previous study demonstrated that Ca ( 2+ ) -permeable cation channels play a role in
IGF-1 induced secretion of
chromogranin A in human neuroendocrine tumor ( NET ) cell line BON [ Mergler et al. : Neuroendocrinology 2006 ; 82 : 87-102 ]
Pugazhenthi et al., J Biol Chem 1999
:
IGF-I stimulated
chromogranin A gene expression by Northern blot analysis 3.7-fold