Gene interactions and pathways from curated databases and text-mining

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CFLAR — WNT11

Text-mined interactions from Literome

Naito et al., Mol Cell Biol 2004 : Conversely, depletion of endogenous cFLIP results in reduced Wnt signaling ... These results indicate that cFLIP-L , in cooperation with FADD, enhances canonical Wnt signaling by inhibiting proteasomal degradation of beta-catenin, thus suggesting an additional mechanism involved with tumorgenesis, in addition to inhibiting Fas signaling
Nakagiri et al., Mol Cell Biol 2005 : Consequently, coexpression of E8 and c-FLIP ( L ) synergistically increased Wnt signaling in 293T cells
Ishioka et al., Genes Cells 2007 : We previously reported that a long form of cFLIP ( cFLIP-L ) inhibits ubiquitylation of beta-catenin and enhances Wnt signaling
Katayama et al., J Cell Sci 2010 : We previously reported that a long form of cFLIP ( cFLIP-L ) enhances Wnt signaling via inhibition of beta-catenin ubiquitylation ... These results suggest a role for nuclear cFLIP-L in the modulation of Wnt signaling