Chiba et al., Exp Gerontol 2008
(Insulin Resistance) :
Here, we tested this notion by analyzing the effect of CR and suppression of growth hormone/insulin-like growth factor-I ( GH/IGF-I ) axis on the expression of resistin, adiponectin, and adipsin genes by rat white adipose tissue ( WAT )
Lowell et al., Endocrinology 1990
:
Differentiation dependent biphasic regulation of adipsin gene expression by insulin and insulin-like growth factor-1 in 3T3-F442A adipocytes ... Because hyperinsulinemia is frequently associated with obesity, we evaluated the effects of this hormone and insulin-like growth factor 1 (IGF-1) on adipsin secretion and adipsin messenger RNA ( mRNA ) levels in 3T3-F442A adipocytes