Gene interactions and pathways from curated databases and text-mining

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CASP7 — CEP44

Text-mined interactions from Literome

Troy et al., J Neurochem 2001 (Alzheimer Disease) : Finally, CEP-1347 blocked A beta stimulated activation of caspase-2 and -3, placing these downstream of JNK activation
Wu et al., J Cell Biochem 2001 : CEP treatment induced activation of caspase-9 and -3 accompanied by cleavage of PARP, Bid, lamin B1, and DFF45/ICAD in both Jurkat and K562 cells, whereas caspase-8 activation and Akt cleavage were observed only in Jurkat cells
Wu et al., Cell Signal 2002 (Leukemia...) : Unexpectedly, pretreatment with a specific p38 inhibitor, SB203580, promoted CEP induced apoptosis and caspase activation in Jurkat and K562 cells, whereas pretreatment with an MEK-1 inhibitor PD98059 inhibited CEP induced apoptosis and caspase activation in K562 cells