Gene interactions and pathways from curated databases and text-mining

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CDKN1A — PLD3

Text-mined interactions from Literome

Kwun et al., FEBS Lett 2003 : Transcriptional repression of cyclin dependent kinase inhibitor p21 gene by phospholipase D1 and D2
Kuribara et al., J Biol Chem 1995 : Synergistic activation of rat brain phospholipase D by ADP-ribosylation factor and rhoA p21 , and its inhibition by Clostridium botulinum C3 exoenzyme ... Interestingly, recombinant isoprenylated rhoA p21 and ARF synergistically activated rat brain PLD ; a similar pattern was seen with the partially purified PLD activating factor ... These findings suggest that rhoA p21 regulates rat brain PLD in concert with ARF, and that isoprenylation of rhoA p21 is essential for PLD regulation in vitro
Carnero et al., Mol Cell Biol 1995 (Second Messenger Systems) : After microinjection, ras-p21 induces a rapid PLD activation followed by a late PLA2 activation