◀ Back to IGF1

CDKN1A — IGF1

Text-mined interactions from Literome

Hiraoka et al., Virchows Arch 2002 (Bone Neoplasms...) : To assess the relationship of p21 ( waf1/cip1 ) to cell differentiation in chondrosarcoma, we examined the p21 expression in 14 cases of chondrosarcoma immunohistochemically and the induction of p21 by insulin-like growth factor-I (IGF-I) during cell differentiation in SW1353 chondrosarcoma cells
Murray et al., Oncogene 2003 : IGF-1 activates p21 to inhibit UV-induced cell death ... In this study, we show that IGF-1 activates p21 protein expression in a p53 dependent manner ... In addition, IGF-1 prevents the UV irradiation mediated suppression of p21 and MDM2 expression ... Taken together, these data indicate that IGF-1 may activate p21 in executing its survival function upon genotoxic insults
Dupont et al., J Biol Chem 2003 (Breast Neoplasms) : These results were confirmed by the expression of a dominant negative construct for MEK-1 suggesting that the increase of the abundance of p21CIP/WAF in response to IGF-1 occurs via the ERK1/2 mitogen activated protein kinase pathway
Yasuda et al., Clin Exp Nephrol 2004 (Acute Kidney Injury) : Insulin-like growth factor-I increases p21 expression and attenuates cisplatin induced acute renal injury in rats
Clark et al., Int J Cancer 2005 (Breast Neoplasms) : Although IGF-I acutely suppressed the p53 response to both agents, it subsequently enhanced the chronic increase in p53 and p21 ( WAF1/Cip1 ), resulting in cell cycle arrest ; however, no apoptosis was observed ... In addition, p21WAF1/Cip1 was increased by IGF-I , which has previously been shown to contribute to the mitogenic response ... Here we demonstrate that with DNA damage IGF-I can also enhance the chronic p53 dependent increase in p21WAF1/Cip1 , culminating in growth arrest
Jiang et al., J Cell Biochem 2006 (Hypertrophy) : IGF-1 increases laminin, cyclin D1, and p21Cip1 expression in glomerular mesangial cells : an investigation of the intracellular signaling pathway and cell-cycle progression ... Here, we investigate IGF-1 regulation of laminin, an extracellular matrix ( ECM ) component, and cyclin D1 and p21Cip1 , cell-cycle progression factor, expressions in glomerular mesangial cells ... Pharmacological inhibition of calcineurin by cyclosporin A blocks IGF-1 induced cyclin D1 and p21Cip1expression significantly ( P < 0.05 )
Devgan et al., J Biol Chem 2006 (MAP Kinase Signaling System) : Although several of these genes are induced by p21 in a MAPK dependent manner, expression of IGF-I is induced upstream of MAPK activation
Jia et al., Immunol Cell Biol 2006 (Atherosclerosis...) : IGF-1 markedly inhibited the expression of p27 ( kip ) and p21 ( cip ) and significantly induced cyclin E and cyclin D ... On the contrary, in symptomatic VSMC there was already increased apoptosis of VSMC and there was no significant effect of IGF-1 or inflammatory cytokines on proliferation, apoptosis or the expression of p27 ( kip ) and p21 ( cip ) and cyclin D and E
Borowiec et al., Biochim Biophys Acta 2011 (Ion Channel Gating) : IGF-1 stimulated p21 ( WAF1/Cip1 ) expression with a kinetic similar to that of cyclin D1, however p27 ( Kip1 ) expression was insensitive to IGF-1
Handayaningsih et al., Biochem Biophys Res Commun 2012 : In p53-null mouse embryonic fibroblasts, the IGF-I induced augmentation of SA-ß-gal and p21 was inhibited, demonstrating that p53 is required for cellular senescence induced by IGF-I
Valverde et al., Exp Cell Res 1995 : Moreover, DBcAMP inhibited in parallel H-ras mRNA expression, p21 ras, and proliferating cellular nuclear antigen protein content induced by IGF-I at 24 and 48 h of culture, respectively, suggesting the involvement of p21 ras in the progression of fetal brown adipocytes through the S phase of the cell cycle and DNA synthesis
Robinson et al., Endocrinology 1994 : Insulin and IGF-I increased the ratio of GTP/GTP + GDP by 31 +/- 9.0 % and 36 +/- 8.0 %, respectively, p21Ras activation by insulin and IGF-I was maximal within 5 min
Wang et al., Biochem Biophys Res Commun 1998 : The aim of this study was to investigate whether IGF I induction of p53 expression and p21 promoter require activation of MAP kinase in cardiac muscle cells ... As expected, PD98059 inhibited induction of p53 mRNA and p21WAF1/CIP1 promoter by IGF I ... These data indicate that transcriptional activation of p53 and p21WAF1/CIP1 by IGF I involves MAP kinase pathway in cardiomyocytes, and thus link MAP kinase to negative modulation of the cell cycle in cardiac muscle cells